Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of gypensapogenin B in anti-tubercle bacillus drugs

A technology of anti-tuberculosis and drugs, applied in the application field of preparing anti-tuberculosis drugs, to achieve the effect of highlighting substantive features, broad application prospects, and expanding types

Active Publication Date: 2014-04-16
顾咏亮
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the irregular treatment and management of tuberculosis patients, irregular chemotherapy and abuse of anti-tuberculosis drugs, the drug resistance of tuberculosis is becoming more and more serious, and the change of drug resistance tends to be multi-drug resistance at the same time. great difficulty at work

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of gypensapogenin B in anti-tubercle bacillus drugs
  • Application of gypensapogenin B in anti-tubercle bacillus drugs
  • Application of gypensapogenin B in anti-tubercle bacillus drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Preparation of Gypensapogenin B tablets of the compound involved in the present invention:

[0017] Take 20 grams of compound Gypensapogenin B, add 180 grams of conventional excipients for preparing tablets, mix them, and prepare 1,000 tablets with a conventional tablet press.

Embodiment 2

[0018] Example 2: Preparation of the compound Gypensapogenin B capsule of the present invention:

[0019] Take 20 grams of the compound Gypensapogenin B, add 180 grams of conventional auxiliary materials for preparing capsules, such as 180 grams of starch, and mix them well, and encapsulate them to make 1000 tablets.

[0020] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0021] Experimental Example 1 Determination of the absolute concentration of Gypensapogenin B against BCG (BCG) by solid medium dilution method

[0022] Scrape the BCG culture from the inclined surface, add it to 3ml Middlebrook 7H9 broth medium, add a small amount of glass beads, tighten the cap of the test tube, grind vigorously on a vortex shaker, and compare it to a standard MacFarland turbidity tube (MacFarland No.1). ) Turbidity, that is, 1mg / ml Bacille Calmette-Guerin (BCG) bacterial suspension.

[0023] Dilute Gypensapogenin B with DMSO into a high-concentration stock solution, dilute the stock solution with sterile ultrapure water containing 5% Tween-80 to the required concentration, add the diluted Gypensapogenin B to 4ml Middlebrook 7H11 agar medium according to the required dose (The medium has been autoclaved at 121°C for 15 minutes and cooled to 50~55°C), mix well, and make Gypensapogenin B with concentrations of 6.0 ug / ml, 4.0 ug / ml, 3.0 ug / ml, 2.0 ug / ml, 1.5 ug / ml,...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses application of gypensapogenin B to preparation of anti-tubercle bacillus drugs. According to the high tubercle bacillus morbidity and the emergence of mycobacterium tuberculosis multiple-resistant strain, the tubercle bacillus morbidity and mortality are one the rise; and gypensapogenin B has remarkable tubercle bacillus suppression activity and good application prospect. The application of gypensapogenin B to the preparation of the anti-tubercle bacillus drugs is firstly publicized, the skeleton type is brand-new, the tubercle bacillus suppression activity is unexpectedly strong and the possibility of giving any revelation by other compounds does not exist, so that prominent substantive features are provided and a remarkable progress in the prevention and treatment of the tubercle bacillus infection is made at the same time.

Description

Technical field [0001] The invention relates to the application field of pharmaceutical compounds, in particular to the application of Gypensapogenin B in the preparation of anti-tuberculosis drugs. Background technique [0002] In recent years, the incidence of tuberculosis in the world has been increasing. According to estimates by the World Health Organization (WHO), the current global population infected with Mycobacterium tuberculosis (MTB) accounts for one third of the world’s population, of which 5-10% The infected person becomes a tuberculosis patient. There are 1.3 million cases of active tuberculosis in my country every year, among which about 600,000 cases are infectious tuberculosis, among which about 600,000 cases are infectious tuberculosis. It is one of the countries with a high burden of tuberculosis in the world. [0003] Since the advent of anti-tuberculosis drugs, the treatment of tuberculosis has made an epoch-making change. However, because the treatment and ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/58A61P31/06
Inventor 施桦王慧吴俊华
Owner 顾咏亮
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com