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Chemical processes generating solid (s) carried out continuously within microreactors

A micro-reactor, solid-state technology that can be used in the continuous field to solve problems such as unrevealed possibilities, and achieve the effects of flexible scaling, controlled thermal management, and precise stoichiometric ratio control.

Inactive Publication Date: 2013-01-02
CORNING INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The prior art never discloses the above-mentioned amide bond formation reaction in a microreactor in a continuous manner

Method used

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  • Chemical processes generating solid (s) carried out continuously within microreactors
  • Chemical processes generating solid (s) carried out continuously within microreactors
  • Chemical processes generating solid (s) carried out continuously within microreactors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Solution A1: 10.5 g of Z-Gly-OH and 32.1 mL of triethylamine (0.4M amino acid) dissolved in 93 mL of toluene

[0086] Solution B1: 7.4 mL of trimethylacetyl (pivaloyl) chloride (0.4 M) dissolved in 143 mL of toluene

[0087] Solution C1: 200 ml water

[0088] Solution D1: 12 ml of isobutylamine (0.6M) dissolved in 200 ml of toluene.

[0089] In said Example 1, S1=toluene and S2=water.

Embodiment 2

[0091] Solution A2: 10.5 g of Z-Gly-OH and 32.1 mL of triethylamine (0.4 M amino acid) dissolved in 93 mL of ethyl acetate

[0092] Solution B2: 7.4 mL of trimethylacetyl (pivaloyl) chloride (0.4 M) dissolved in 143 mL of ethyl acetate

[0093] Solution C2: 200 ml of water containing 10% by weight of NaCl.

[0094] Solution D2: 12 ml of isobutylamine (0.6M) dissolved in 200 ml of ethyl acetate.

[0095] In said Example 2, S1 = ethyl acetate and S2 = water containing NaCl.

[0096] Flow rate and experimental setup

[0097] Solution A (A1 (Example 1) and A2 (Example 2)) and Solution B (respectively B1 and B2) were mixed with solution C (respectively C1 and C2) at a flow rate of 10 g / min (flow rate 15 g / min) are pumped into the non-mixing fluid compartment 10 together, and the temperature of the fluid compartment 10 is maintained at 5-10°C. In this compartment 10 the activated ester of Z-Gly is formed. The reaction was then quenched in the second mixing fluid chamber 20 with ...

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Abstract

The present invention relates to a continuous process for conducting a chemical reaction in a liquid reaction medium. Characteristically: - said continuous process is carried out in a microreactor (10), - said chemical reaction produces a solid insoluble in said liquid reaction medium, and - said continuous process comprises the continuous extraction of said solid, as it is produced, with a solvent S2, immiscible with said reaction medium. Such a process is advantageously carried out for conducting the activation of a carboxylic acid in the presence of an organic base.

Description

[0001] This application claims priority from European Patent Application No. 10305190.0, filed 25.02.2010. technical field [0002] The invention relates to a continuous process for carrying out chemical reactions in a liquid reaction medium. The present invention relates more particularly to a continuous process operating in microreactors for carrying out chemical reactions that produce solids (sediments) that are insoluble in the liquid reaction medium while avoiding the risk of clogging form. Background of the invention [0003] Many chemical reactions produce solids (precipitates) that are insoluble in the reaction medium. If such reactions are to be performed in a continuous flow device, some difficulties may arise because solids within the channels may easily condense and plug the channels. This phenomenon effectively stops the continuous flow. [0004] A common reaction that forms a solid (precipitate) is the amide bond formation reaction in peptide synthesis, whic...

Claims

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Application Information

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IPC IPC(8): B01J19/00
CPCB01J19/0093B01J2219/00905B01J2219/0086B01J2219/00889B01J2219/00867B01J2219/00869C07K1/02B01J2219/00873
Inventor S・范祖特芬张飞霞
Owner CORNING INC
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