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Applications of pterostilbene in preparation of medicines for preventing and treating chronic glomerular disease

A technology of pterostilbene and glomerulus, which is applied in the directions of drug combination, urinary system diseases, ether/aldehyde acetal active ingredients, etc., can solve the problems of obvious side effects, limited improvement effect, etc. targeted effect

Active Publication Date: 2014-11-19
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The improvement effects of the above drugs are limited, and the side effects are obvious

Method used

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  • Applications of pterostilbene in preparation of medicines for preventing and treating chronic glomerular disease
  • Applications of pterostilbene in preparation of medicines for preventing and treating chronic glomerular disease
  • Applications of pterostilbene in preparation of medicines for preventing and treating chronic glomerular disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1: The therapeutic effect of pterostilbene on glomerular lesions in fructose model rats.

[0028] Experimental animals: SD rats, 200-220 grams, male.

[0029] Drug preparation: select tablets for the prevention or treatment of glomerular diseases with a pterostylbene content of 40 mg / tablet, ultrasonically disperse them in normal saline, and use them for intragastric administration with a dosage of 40 mg / kg.

[0030] Experimental instruments: high-speed refrigerated centrifuge, tissue slicer, microplate reader, optical microscope, transmission electron microscope, etc.

[0031] experimental method:

[0032] 1. Establishment of the model: After adapting to the environment for one week, the animals were randomly divided into a model group and a normal group, with 30 animals in each group. Modeling of fructose rat model: Drinking water was given 10% fructose solution; normal group was given tap water, and the modeling period was 70 days.

[0033] 2. After 4 week...

Embodiment 2

[0047] Dissolve pterostilbene in water and an appropriate amount of solubilizer (polyethylene glycol 400) according to the conventional preparation method, subpackage, and sterilize to prepare an oral liquid for the prevention or treatment of glomerular diseases with a pterostilbene content of 20 mg / ml;

[0048] Pterostilbene is prepared according to conventional preparation methods, gelatin and sorbitol are selected as soft capsule materials, and the content of pterostilbene is 20mg / capsules for the prevention or treatment of glomerular diseases;

[0049]Pterostilbene is added with excipient cyclodextrin according to a conventional preparation method, mixed uniformly, granulated, and tabletted to prepare tablets for prevention and treatment of glomerular diseases with a content of pterostilbene of 20 mg / tablet.

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Abstract

The invention relates to new medical applications of a natural monomer compound pterostilbene, in particular to applications of the pterostilbene in preparation of medicines for preventing and treating a chronic glomerular disease, and applications of pterostilbene in preparation of medicines for preventing and treating progressive chronic glomerular disease. Animal test results show that the pterostilbene has an obvious effect on prevention and improvement of a glomerular function and an organic injury of a fructose model rat renal. The pterostilbene is matched up with relevant adjuvants, a conventional preparation method can be utilized to obtain a health care product or a medicine aiming at preventing and treating the glomerular disease. The above health care product and the medicine can be used for the diseases relevant to the chronic glomerular lesion, such as diabetes and metabolic syndrome and the like, so that the glomerular progressive course in the relevant diseases can be delayed and improved.

Description

1. Technical field: [0001] The present invention relates to a new medical application of natural plant active ingredient pterostilbene, in particular to the application of pterostilbene in the preparation of drugs for the prevention and treatment of chronic glomerular diseases, especially for the preparation of drugs for progressive chronic glomerular diseases Application in preventive and therapeutic agents. 2. Background technology: [0002] Pterostilbene (Pterostilbene, CAS No. 537-42-8), is a natural active ingredient that belongs to resveratrol derivatives, and is used in grapes, blue strawberries, dried blood products, Indian jina trees and Indian anti-diabetic herbal medicine "Bijasar". "The important active ingredient in. [0003] The prevalence of diabetes in China is 9.7%, which is higher than the world average of 6.4%, and China has become the world's largest diabetic country. There are as many as 150 million people at high risk of diabetes in my country. With ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/09A61P13/12
Inventor 孔令东王伟潘颖丁晓琴
Owner NANJING UNIV
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