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Treatment of nerve injuries

A nerve injury, neuron technology, applied in the field of regeneration of nerves and nerve function

Inactive Publication Date: 2012-12-19
UNIVERSITAETSKLINIKUM HAMBURG EPPENDORF
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, only Neuropilin-2 has been identified in human dendritic cells as another carrier of PSA in mammalian class (Curreli et al., 2007), but remains to be confirmed, Does neuropilin-2 expressed in the brain also carry PSA

Method used

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  • Treatment of nerve injuries
  • Treatment of nerve injuries
  • Treatment of nerve injuries

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Experimental program
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Embodiment

[0122] Antibodies and Reagents

[0123] Anti-human histone H1 rabbit polyclonal antibody (Santa Cruz Biotechnology, Heidelberg, Germany), anti-histone H1 mouse monoclonal antibody AE-4 (Millipore / Upstate, Schwalbach, Germany), horseradish peroxidase (HRP)-conjugated NeutrAvidin (Thermo Scientific / Pierce, Bonn, Germany), HNK-1 antibody 412 (Kruse et al., 1984) and anti-BrdU mouse antibody G3G4 (Developmental Studies Hybridoma Bank, USA Iowa City, IA), and a polyclonal rabbit antibody against human glyceraldehyde-3-phosphate dehydrogenase (Abcam, Cambridge, UK). Anti-PSA mouse monoclonal IgG2a antibody 735 (Frosch et al., 1985) and endoglycosidase N were provided by Dr. Rita Gerardy-Schahn (Zentrum Biochemie, Chemie, Medizinische Hochschule, Hannover, Germany) as a kind gift. The secondary antibody was purchased from Dianova (Dianova USA Inc., New York, USA). Histone H1 (#14-155, bovine histone H1.4) was purchased from Millipore / Upstate (Millipore), glyceraldehyde-3-phosphate...

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Abstract

This invention relates to treatment of nerve injuries and regeneration of nerves and nerve function in the acutely and chronically lesioned central and peripheral nervous system. The invention provides a pharmaceutical composition comprising histone, e.g., H1. It was surprisingly shown that histones, in particular histone Hl, can be used for the preparation of a pharmaceutical composition for treatment and / or prevention of acute and chronic injuries to the central and peripheral nervous system, for promoting growth and / or regrowth of nerves and enhancing formation of synapses and synaptic plasticity, and for neuroprotection.

Description

technical field [0001] The present invention relates to the treatment of nerve injuries, especially traumatic, acute and / or chronic injuries of the central and peripheral nervous system, and also to the regeneration of nerves and nerve functions. The present invention provides a pharmaceutical composition comprising histone, especially histone H1. It has surprisingly been demonstrated that histones can be used for the preparation of pharmaceutical compositions for the treatment and / or prevention of acute and chronic injuries to the central and peripheral nervous system, for the promotion of growth and / or regeneration of nerves and enhance synapse formation and synaptic plasticity, and for neuroprotection. Background technique [0002] Polysialic acid (PSA) is known to play an important role in the development and function of the nervous system. It has also been associated with the regeneration of neural function. PSA is a long linear polymer composed entirely of negativel...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61P25/00
CPCA61K38/17A61K48/00A61P25/00C07K14/4702
Inventor M·沙奇纳R·克里尼B·米斯拉
Owner UNIVERSITAETSKLINIKUM HAMBURG EPPENDORF
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