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Botanical antiviral agent, and preparation method and application thereof

An antiviral agent and plant-derived technology, applied in botany equipment and methods, plant growth regulators, applications, etc., can solve the problems of lack of single-compound pesticide varieties, drug residues, pesticide pollution, etc.

Active Publication Date: 2012-12-12
SHAANXI SUNGER ROAD BIO SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current situation of domestic viral pesticides is: (1) Due to the absolute parasitism of the virus on the host (specialized parasitism), the energy and materials required for its replication are provided by the host cell. Although there are many mixed preparations, there is a lack of direct action on the virus. Single-compound pesticide varieties, resulting in poor control effect
(2) At present, the vast majority of drugs registered in China use morpholine hydrochloride as the main ingredient, and morpholine hydrochloride has long been used as medicine for the treatment of clinical viral diseases. If it is used for a long time in food crops, fruits and vegetables, etc. Cause drug residues, long-term consumption of food with pesticide residues usually leads to drug resistance problems in the human body
(3) The long-term and large-scale use of chemical virus preparations will cause serious "pesticide public hazards"
At present, there are few reports on the functional research and antiviral application development of compounds contained in Malvaceae plants. If you can successfully screen and develop biologically active sterenol compounds from Malvaceae plants, it will be beneficial to pesticides, especially It is of great significance in the field of antiviral related research

Method used

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  • Botanical antiviral agent, and preparation method and application thereof
  • Botanical antiviral agent, and preparation method and application thereof
  • Botanical antiviral agent, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: the preparation of the former medicine of Malvaceae plant extract

[0033] (1) Collect the branches, leaves and bark of Malvaceae plants, dry and crush them for later use;

[0034] (2) Fully soak the pulverized material in water according to the weight volume ratio of 1:1;

[0035] (3) Add three times the volume of ethyl acetate for extraction, and filter to obtain the extract;

[0036] (4) The residue of the material was repeatedly extracted with ethyl acetate once, and the re-extraction solution was obtained by filtration, and the residue was discarded;

[0037] (5) Combine the initial extraction solution and the re-extraction solution;

[0038] (6) Concentrating the combined extracts under reduced pressure to obtain the original drug.

[0039] After testing, the content of sterenol compounds in the original drug prepared in this embodiment is 10% by weight.

Embodiment 2

[0040] The preparation of embodiment 2 aqua

[0041]Add 12.0L of the original drug prepared in Example 1, 2.0L of acetonitrile and 2.5L of OP-10 in the preparation kettle, and stir for 40min at room temperature to obtain 16.5L of the pesticide water agent. In the water agent, the sterol compound The content is 7.2% by weight.

Embodiment 3

[0042] The preparation of embodiment 3 emulsifiable concentrates

[0043] Take 110ml of the original drug prepared in Example 1, add 100ml of acetonitrile and 16ml of OP-1, and stir at room temperature for 40min to obtain 226ml of emulsifiable concentrate, the content of sterols in this emulsifiable concentrate is 4.9% by weight.

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Abstract

The invention relates to a botanical antiviral agent. A hibiscus mutabilis extract active compound using steroid enol compounds as effective components is adopted as an active component, in the terms of the total weight of the antiviral agent, the hibiscus mutabilis extract active compound accounts for 0.01-75wt% and an assistant accounts for 99.9-25wt%, wherein the content of the steroid enol compounds in the hibiscus mutabilis extract active compound is 0.05-20wt%. The invention also provides a preparation method and an application of the antiviral agent. A plurality of indoor and outdoor experimental results prove that the antiviral agent can be applied to control of multiple virus diseases of multiple kinds of plants, and the comprehensive control effect can be up to 72-82 percent. The antiviral agent is a botanical pesticide with innocuity to human beings and livestocks.

Description

technical field [0001] The invention relates to a plant-derived antiviral agent, which contains Malvaceae plant extract with stenol compounds as active ingredients, and optionally contains auxiliary agents. The antiviral agent of the invention has good antiviral activity and is a natural, efficient and safe plant-source antiviral pesticide preparation. Background technique [0002] Plant viral diseases pose a serious threat to crop yield and quality worldwide, causing a 10-30% reduction in yield and an economic loss of about 20 billion U.S. dollars each year. my country is a large agricultural country, and the economic losses caused by viral diseases to food production, horticultural crops, and cash crops amount to more than tens of billions of yuan every year. Therefore, there is an urgent need to develop antiviral drugs. Foreign countries have increased research in this area since the early 1960s. In 1985, the alginic acid casein (Mosanon) registered in Japan was extract...

Claims

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Application Information

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IPC IPC(8): A01N65/08A01P1/00
Inventor 吴云锋
Owner SHAANXI SUNGER ROAD BIO SCI
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