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Drug loaded coating and its preparation method

A drug-loaded coating and drug-loaded technology, which is applied in coatings, medical science, surgery, etc., can solve the problems of easy peeling off of the hydrophilic surface and difficult synthesis, and achieve the goals of increasing drug loading, avoiding environmental pollution, and prolonging the cycle. Effect

Active Publication Date: 2012-10-17
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The invention solves the problem of preparing drug-loaded nano-microspheres with stable hydrophilic surface structure from biodegradable polymers or random copolymers, and makes up for the need to use amphiphilic block copolymers or hydrophilic block copolymers that are difficult to synthesize in the prior art. Insufficient that the water surface layer is easy to fall off

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] (1) preparation of chitosan film layer

[0046] Coating chitosan-acetic acid-water solution (the mass concentration of chitosan is 2%, the mass ratio of acetic acid and water: 3:100) on the surface of the metal bracket whose main body is stainless steel, the coating amount is 0.08 grams, and then the coating Put the metal bracket with chitosan acetic acid-water solution in 20°C absolute ethanol, take it out after shaking for 20 minutes; then place it in fresh 20°C absolute ethanol, shake it for 20 minutes and take it out to completely elute the acetic acid; Dry in a vacuum oven at 35°C for 30 minutes, remove ethanol, and obtain a lactide and glycolide copolyester fiber scaffold with a chitosan coating. The amount of chitosan is 1.6 mg. After the atomic force microscope test, the thickness of the coating is is 1.2 μm.

[0047] (2) Preparation of drug-loaded nano-submicron particle aqueous dispersion

[0048] Take 20mg of polycaprolactone, add 20ml of acetone to make a ...

Embodiment 2

[0052] (1) preparation of chitosan film layer

[0053] Coating chitosan-acetic acid-water solution (the mass concentration of chitosan is 4%, the mass ratio of acetic acid and water is: 5:100) is coated on poly(anhydride ester) salicylic acid stent surface, coating amount is 0.05 gram, then Put the metal stent coated with chitosan acetic acid-water solution in 30°C absolute ethanol, shake it for 10 minutes and then take it out; put it in fresh 30°C absolute alcohol, shake it for 10 minutes and take it out to completely elute the acetic acid Then dry in a vacuum oven at 55°C for 15 minutes to remove ethanol, and obtain a poly(anhydride ester) salicylic acid stent with a chitosan coating. The amount of chitosan is 2 mg. After the atomic force microscope test, the coating thickness is 1.4 μm.

[0054] (2) Preparation of drug-loaded nano-submicron particle aqueous dispersion

[0055] Take 900mg of polycaprolactone, add 30ml of acetone to make a solution with a concentration of 3...

Embodiment 3

[0059] (1) preparation of chitosan film layer

[0060] It is 6mm in diameter and 45mm in length to be woven into lactide and glycolide copolyester fibers with a diameter of 0.2mm. The mass concentration is 4%, the mass ratio of acetic acid to water is: 5:100), the coating amount is 0.06 g, and then the metal stent coated with chitosan acetic acid-water solution is placed in absolute ethanol at 30°C and shaken for 10 Take it out after 10 minutes; then put it in fresh 30°C absolute ethanol, shake it for 10 minutes and take it out to elute the acetic acid thoroughly; then dry it in a vacuum oven at 50°C for 15 minutes to remove the ethanol, and you can get chitosan-coated Lactide and glycolide copolyester fiber scaffold, the amount of chitosan is 2.4mg, after the atomic force microscope test, the coating thickness is 1.6μm.

[0061] (2) Preparation of drug-loaded nano-submicron particle aqueous dispersion

[0062] Take 900mg of polycaprolactone, add 30ml of acetone to make a so...

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Abstract

The invention relates to a drug loaded coating and its preparation method, especially to a thermoplastic degradable fiber woven scaffold coating and its preparation method. The drug loaded coating provided by the invention is a drug loaded thin layer formed on a chitosan thin layer on the surface of the scaffold. The preparation method of the degradable drug loaded coating comprises the following steps of: (1) coating the surface of the degradable fiber woven scaffold with a chitosan-acetic acid-aqueous solution, placing into anhydrous ethanol, removing ethanol to form a chitosan coating; (2) coating the chitosan coating with a drug loaded polymer microsphere dispersion, and removing moisture to form a drug loaded polymer coating; and (3) continuously coating the drug loaded polymer dispersion, and increasing and adjusting drug loading and drug loaded kind. The method for preparing the drug loaded coating is simple and is convenient to regulate and control drug loaded kind, coating thickness and drug loading.

Description

technical field [0001] The invention relates to a drug-loaded coating and a preparation method thereof, in particular to a coating of a thermoplastic degradable fiber braided stent and a preparation method thereof, in particular to a chitosan drug-loaded thin layer formed on the surface of the stent Drug-loaded coatings on film layers and methods for their preparation. Background technique [0002] A stent is a device used to support the internal pipes of the human body, and has the function of preventing these pipes from being blocked or narrowed. The surface of the stent is often coated with drugs to prevent the growth and aggregation of human tissue or the reproduction of bacteria on the surface of the stent, so as to ensure the smoothness of the human pipeline. At present, the methods for synthesizing polymer drug-loaded nano-microspheres mainly include soap-free emulsion polymerization, dispersion polymerization and self-assembly method. Soap-free emulsion polymerizat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/06A61L31/16
Inventor 赵炯心徐敏张幼维张秀芳陈南梁李文刚
Owner DONGHUA UNIV
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