Application of specific antibodies in preparation of biological products for controlling virus infection based on virus acceptor binding site selection

A receptor binding, biological product technology, applied in the direction of antibodies, antiviral agents, etc., can solve the problem of placing the 2F5 recognition sequence, unable to present the conformation, etc., to achieve the effect of good virus infection and prevention and control of virus infection

Inactive Publication Date: 2012-10-17
SICHUAN HUIYU PHARMA
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

One explanation is that these vaccines do not place the 2F5 recognition sequence in a suitable environment and therefore cannot present the correct conformation

Method used

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  • Application of specific antibodies in preparation of biological products for controlling virus infection based on virus acceptor binding site selection
  • Application of specific antibodies in preparation of biological products for controlling virus infection based on virus acceptor binding site selection

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Embodiment Construction

[0013] The present invention will be further described in detail below in conjunction with specific embodiments, but the embodiments of the present invention are not limited to the following examples.

[0014] The example of this case is based on the application of specific antibodies based on the selection of virus receptor binding sites in the preparation of biological products for the prevention and treatment of viral infections. The heavy chain variable region gene VH of the specific antibody contains amino acids with sequences of GYNFASEW, IYPGDSDT, ARQNHYGSGSYFYRTAYYYAMDV Three CDRs, specific antibody light chain variable region gene VL contains three CDRs with amino acid sequence QSISSY, AAS, QQSYNTPFT.

[0015] The monoclonal antibody of this embodiment has variable heavy chain and variable light chain sequences, and the specific sequence of the heavy chain variable region gene VH is:

[0016] Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu

[0017] ...

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Abstract

The invention discloses an application of specific antibodies in the preparation of biological products for controlling virus infection based on virus acceptor binding site selection. The heavy chain variable gene VH of the specific antibodies comprises one or more CDRs in amino acid sequences containing GYNFASEW, IYPGDSDT and ARQNHYGSGSYFYRTAYYYAMDV, the heavy chain variable gene VL of the specific antibodies comprises one or more CDRs in amino acid sequences containing QSISSY, AAS and QQSYNTPFT, and the specific antibodies having above amino acid sequence are selectively combined with gp41MPER. According to the invention, the specific antibodies having specific sequences are selectively combined with the gp41MPER, so the antibodies and viruses undergo a good neutral reaction, thereby the antibodies play good roles in the control of the virus infection.

Description

technical field [0001] The invention belongs to the field of biology, and in particular relates to the application of a specific antibody based on selecting a virus receptor binding site in the preparation of biological products for preventing and treating virus infection. Background technique [0002] With the continuous development of the world economy, spatial distance is no longer an obstacle to people's communication, but with this progress, infectious diseases caused by various viruses have also spread all over the world. Among them, the harm caused by AIDS caused by retrovirus is the most noticeable, and millions of people die of AIDS every year. [0003] Neutralizing antibodies play a vital role in resisting viral infection. The process of retrovirus entry into cells includes adsorption, receptor binding, membrane fusion, and the delivery of viral content, mainly nucleic acids and enzymes, into cells. Neutralizing antibodies bind to proteins on the surface of the v...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395A61P31/14A61P31/20
Inventor 丁兆朱仲玉
Owner SICHUAN HUIYU PHARMA
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