Tilmicosin soluble powder and preparation method thereof

Abstract

The invention discloses tilmicosin soluble powder, which consists of the following components in parts by weight: 1-50 parts of tilmicosin, 1-50 parts of a solid dispersoid carrier auxiliary material and 0-70 parts of a medical filling auxiliary material. The invention further discloses a preparation method of the tilmicosin soluble powder. The method comprises the following steps of: (1) adding the solid dispersoid carrier auxiliary material into a solubilizing assistant for dissolving; (2) adding tilmicosin, stirring and dissolving; and (3) drying. The tilmicosin soluble powder disclosed by the invention has the advantages of low water content, high solubility, high bioavailability and convenience for administration, and the palatability of animals can be improved simultaneously.

Description

technical field [0001] The invention relates to veterinary drugs, in particular to a tilmicosin soluble powder and a preparation method thereof. Background technique [0002] Tilmicosin is a macrolide broad-spectrum antibiotic specially used for livestock and poultry. It is mainly used to prevent and control livestock pneumonia, avian mycoplasma disease and mastitis of lactating animals. It has been widely used in animal husbandry production. At present, the dosage forms included in the national standards include premixes, soluble powders, solutions and injections. Tilmicosin is insoluble in water, and liquid preparations (including oral liquids and injections) need to add a large amount of organic solvents as solubilizers, co-solvents and stabilizers, which have the following defects: first, stability is difficult to guarantee and in Potential hazards such as allergies, stress, or high toxicity are likely to be caused to animals during application; second, the use of a lar...

AI Technical Summary

Problems solved by technology

Tilmicosin is insoluble in water, and liquid preparations (including oral liquids and injections) need to add a large amount of organic solvents as solubilizers, co-solvents and stabilizers, which have the following defects: first, stability is difficult to guarantee and in Potential hazards such as allergies, stress, or high toxicity are likely to be caused to animals during application; second, the use of a large amount of organic solvents also has adverse effects on the environment and increases production costs; third, liquid preparations are inconvenient and difficult to store during transportation Fourth, when the injection dosage form is used clinically, the labor intensity of animal injection is high, the stress on the animal is large, and it is easy to cause death due to the injection of cardiac drugs.

[0003] The Chinese invention patent with the patent number ZL 200810154395.5 discloses a soluble and stable tilmicosin composition, which can be made into soluble powder, but because it contains acidic substances with high water content, it is easy to produce and store. Agglomeration causes product deterioration and discoloration, and at the same time, part of the tilmicosin floats on the water surface for a long time without dissolving and blocks the drinking water pipe when the drug is administered through the drinking water pipe due to uneven mixing, and the drug utilization rate is low; secondly, the composition also There is a defect that the bioavailability is low, so that the drug cannot play its role well

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