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Preparation method of electrostatic spinning fibers with axial-orientation structures on cylindrically tubular support and device for realizing same

An axially oriented, cylindrical technology, used in textile and papermaking, medical science, fiber processing, etc., to solve problems such as inability to rotate the device, limiting the length of tubular stents, and uneven fiber deposition.

Inactive Publication Date: 2012-07-11
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method also has its limitations: first, the device cannot be rotated, resulting in uneven fiber deposition; second, the air column cannot effectively support the tubular scaffold, and once the distance is too long, the fibers tend to accumulate into yarns or fibers bundle, thus limiting the length of the tubular stent

Method used

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  • Preparation method of electrostatic spinning fibers with axial-orientation structures on cylindrically tubular support and device for realizing same
  • Preparation method of electrostatic spinning fibers with axial-orientation structures on cylindrically tubular support and device for realizing same
  • Preparation method of electrostatic spinning fibers with axial-orientation structures on cylindrically tubular support and device for realizing same

Examples

Experimental program
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Effect test

Embodiment 1

[0029] According to the aforementioned method for preparing a cylindrical tubular stent with an axially oriented structure in the present invention, including the preparation of spinning solution, the collection of electrospun fibers and the steps of taking out and storing the tubular stent, the following process conditions are adopted:

[0030] (1) Dissolve 0.8 g of collagen in 10 ml of hexafluoroisopropanol, stir magnetically for 12-24 hours until completely dissolved, and obtain a collagen solution with a concentration of 8% (g / ml).

[0031] (2) Electrospinning is carried out through a rotating receiving device, spinning conditions: voltage 15 kV; receiving distance 150 mm; spinning rate, 1.0 ml / hour, rotation rate 10 rpm, diameter of the insulating section of the rotating shaft 2 mm, length 20 mm.

[0032] (3) After 2 hours of continuous electrospinning, the rotating shaft was removed, and the fiber membrane deposited on it was drawn out to obtain a tubular scaffold of col...

Embodiment 2

[0035] According to the aforementioned method for preparing a cylindrical tubular stent with an axially oriented structure in the present invention, including the preparation of spinning solution, the collection of electrospun fibers and the steps of taking out and storing the tubular stent, the following process conditions are adopted:

[0036] (1) Dissolve 0.75 g of polylactic acid in 10 ml of hexafluoroisopropanol, stir magnetically for 12-24 hours until completely dissolved, and obtain a polylactic acid solution with a concentration of 7.5% (g / ml).

[0037] (2) Electrospinning is carried out through a rotating receiving device, spinning conditions: voltage, 12 kV; receiving distance, 150 mm; spinning rate, 1.0 ml / hour, rotation rate 50 rpm, diameter of the insulating section of the rotating shaft 3 mm , length 20 mm.

[0038] (3) After 5 hours of continuous electrospinning, the rotating shaft was removed, and the fiber film deposited on it was drawn out to obtain a polylac...

Embodiment 3

[0041] According to the aforementioned method for preparing a cylindrical tubular stent with an axially oriented structure in the present invention, including the preparation of spinning solution, the collection of electrospun fibers and the steps of taking out and storing the tubular stent, the following process conditions are adopted:

[0042] (1) Dissolve 1.0 g of polycaprolactone in 10 ml of dichloromethane, and magnetically stir for 12-24 hours until completely dissolved to obtain a polycaprolactone solution with a concentration of 10% (g / ml).

[0043] (2) Electrospinning is carried out through a rotating receiving device, spinning conditions: voltage, 20 kV; receiving distance, 20 mm; spinning rate, 1.5 ml / hour, rotation rate 50 rpm, diameter of the insulating section of the rotating shaft 10 mm , length 50 mm.

[0044] (3) After continuous electrospinning for 6 hours, the rotating shaft was removed, and the fiber film deposited on it was drawn out to obtain a tubular sc...

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Abstract

The invention relates to a preparation method of electrostatic spinning fibers with axial-orientation structures on a cylindrically tubular support and a device for realizing the same. The preparation method includes: (1) preparing spinning solution; and (2) utilizing the spinning solution for electrostatic spinning, depositing fibers directionally on a cylindrical insulation rotary shaft of a receiving device by the aid of the receiving device, drawing out fiber films deposited on the rotary shaft and drying the same in the vacuum environment to obtain the electrostatic spinning cylindrically tubular support. The receiving device for preparing the electrostatic spinning fibers with the axial-orientation structures on the cylindrically tubular support comprises a motor, a belt conveying device, a rotary transmission shaft and a rotary collection shaft, the motor is connected with the rotary transmission shaft, the belt conveying device drives two ends of the rotary collection shaft to rotate synchronously, the rotary collection shaft is divided into three sections, the middle section is an insulation cylinder, the rest two sections are metal cylinders, and the head end and the tail end of the rotary collection shaft are connected with the two metal cylinders and are fixed and driven to rotate by the same. The preparation method has higher operability, the receiving device used in the preparation method is novel and reasonable in structure, and prepared fibers on the tubular support have high orientation and are arranged directionally axially along a support shaft.

Description

technical field [0001] The invention belongs to the field of preparation and device of electrospinning support materials, and in particular relates to the preparation and device of an electrospinning cylindrical tubular support with an axial orientation structure. Background technique [0002] Electrospinning technology has been developed rapidly in the past decade, and it is one of the effective ways to prepare nanofibers. The fibrous scaffold prepared by electrospinning has the characteristics of high porosity, low pore size and high specific surface area, and has wide application potential. [0003] Typically, electrospun fibers are deposited on the receiving device in a random manner, which limits their application in tissue engineering, especially tissue engineering for nerve repair. Because a large number of studies have shown that when the electrospun fibers are aligned along the axial direction of the nerve conduit, nerve cells will grow along the direction of the f...

Claims

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Application Information

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IPC IPC(8): D01D5/00A61F2/00
Inventor 柯勤飞黄晨莫秀梅林童
Owner DONGHUA UNIV
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