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Hard-shell capsule based on pullulan

A pullulan polysaccharide and hard shell technology, which is applied in the composition and production of plant-derived hard shell capsules, can solve the problems of poor storage stability of pullulan polysaccharide hard shell capsules, deepening of capsule shell color, and easy brittleness, etc. , to achieve the effect of eliminating the stage of water absorption and swelling, easy to dissolve, and saving production time

Active Publication Date: 2012-06-20
SHANXI JC BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during use, it was found that the storage stability of pullulan hard-shell capsules is poor. After long-term storage, not only the color of the capsule shell becomes darker, but also it is prone to brittleness, and it is easy to fall off when filling the medicine.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Add 175kg of pure water into a 600L sol tank, raise the temperature to 90°C, turn on the stirring, slowly add 40kg of pullulan, 650g of gellan gum, 1.2g of potassium dihydrogen phosphate, 270g of glycerin, 400g of calcium lactate, and mix and stir for 0.5hr. Until a uniform solution is formed, then the temperature is lowered to 65°C, and vacuum defoaming is performed under slow stirring.

[0029] According to the specifications and sizes of gelatin hard-shell hollow capsules, the hard capsule shells are made by traditional dipping method on the automatic production line of gelatin hollow capsules, dried at 35-45°C, and the moisture content is controlled to 8-12%. The obtained hard-shell hollow capsule has ideal transparency and elasticity, good taste and high strength, and the filling rate of the medicine is higher than that of the traditional gelatin capsule.

[0030] After testing, the pullulan hard-shell capsule prepared in this example was transparent in appearance,...

Embodiment 2

[0032] Add 160kg of purified water to a 600L sol tank, raise the temperature to 90°C, turn on the stirring, and slowly add 40kg of pullulan, 680g of gellan gum, 300g of locust bean gum, 280g of potassium chloride, 320g of maltitol, and 8g of dioctyl sulfonate Sodium base succinate, 180g sodium pyrophosphate, mix evenly, stir vigorously for 20min until a uniform solution is formed, then cool down to 65°C, vacuumize and defoam under slow stirring.

[0033] According to the specifications and sizes of 00# gelatin hard-shell hollow capsules, the hard capsule shells are made by the traditional dipping method on the full-automatic production line of gelatin hollow capsules, dried at 35-45°C, and the moisture content is controlled to 8-12%. The obtained hard-shell hollow capsule has ideal transparency and elasticity, good taste and high strength, and achieves an ideal filling rate when filled with medicines.

[0034] After testing, the 00# pullulan polysaccharide hard-shell capsule p...

Embodiment 3

[0036] Add 175kg of pure water to a 600L sol tank, raise the temperature to 90°C, turn on the stirring, and slowly add 40kg of pullulan, 450g of gellan gum, 200g of konjac gum, 220g of calcium chloride, 400g of xylitol, and 7g of polysorbate 80, 20g of sodium hexametaphosphate, mix and stir for 0.5hr until a uniform solution is formed, then cool down to 65°C, vacuumize and defoam under slow stirring.

[0037] According to the specifications and sizes of 0# gelatin hard-shell hollow capsules, the hard capsule shells are made by traditional glue-dipping method on the automatic production line of gelatin hollow capsules, dried at 35-45°C, and the moisture content is controlled to 8-12%. The obtained hard-shell hollow capsule has ideal transparency and elasticity, good taste and high strength, and has a high probability of filling when filling medicine.

[0038] After testing, the 0# pullulan polysaccharide hard-shell capsule prepared in this example is transparent in appearance, ...

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PUM

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Abstract

The invention discloses a hard-shell capsule based on pullulan. Based on the total weight of the hard-shell capsule, the hard-shell capsule comprises the following components in percentage by weight: 80-90% of pullulan, 1-10% of hydrophilic gel, 0.1-1% of plasticizer, 0.001-0.1% of water retaining agent, 0.001-3% of surfactant and 8-12% of water. The hard-shell capsule disclosed by the invention can replace a gelatin hard-shell capsule, thereby avoiding the pollution possibly brought by an animal product. The hard-shell capsule disclosed by the invention has the advantages of stable property,good moisture resistance and good transparency; the probabilities of the frangibility and deepening of color are reduced during long-term storage; and the uptake rate of the filling of a medicine is improved.

Description

technical field [0001] The invention relates to the technical field of hard-shell capsules, in particular to a composition of plant-source hard-shell capsules and a production method thereof. Background technique [0002] Capsules are widely used in the pharmaceutical and healthcare products industries. Capsules are solid drug powders and granules packed in a hard-shell capsule. The use of capsules solves the problems of difficult to drink and poor taste of drugs, and truly solves the problem that good drugs no longer taste bitter. [0003] Materials used in the production of hard shell capsules should have good bioavailability and dissolve rapidly, reliably and safely. Traditional hard-shell capsules are made of food-grade gelatin obtained by hydrolyzing the skin or bones of pigs, cattle and other animals as the main raw material, and are carefully processed with auxiliary materials, which must meet the strict requirements for pharmaceutical products. Edible gelatin itsel...

Claims

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Application Information

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IPC IPC(8): A61K9/48
Inventor 李永安曹护
Owner SHANXI JC BIO TECH
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