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Application of (RS)-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazole-1-radical)-hexyl-2-alcohol to preparation of silkworm medicament

A technology of dichlorophenyl and silkworm, which can be used in pharmaceutical formulas, medical preparations containing active ingredients, antifungal agents, etc., and can solve problems such as silkworm medicine without precedent

Inactive Publication Date: 2012-05-02
周元铎
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although it has been applied to pesticides, there is no precedent for silkworm medicine

Method used

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  • Application of (RS)-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazole-1-radical)-hexyl-2-alcohol to preparation of silkworm medicament
  • Application of (RS)-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazole-1-radical)-hexyl-2-alcohol to preparation of silkworm medicament
  • Application of (RS)-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazole-1-radical)-hexyl-2-alcohol to preparation of silkworm medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1: Preparation of (RS)-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)-hexan-2-alcohol solution

[0041] Original drug 800g

[0042] Add solvent to 10000ml

[0043] Divided into 5000 pieces (each 2ml)

[0044] It is prepared by the method of conventional solution medicament, and the process flow chart of preparation is as follows: figure 1 shown. Prescription and basis: After repeated tests, (RS)-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)-hexan-2-ol (Hexaconazole) is 100ppm to the optimal concentration of the prevention and treatment of mycosis of silkworm. After calculation, each ampule bottle contains 2ml liquid medicine, which can be mixed with 1kg quicklime, which is convenient for silkworm farmers to use.

Embodiment 2

[0045] Example 2: Preparation of (RS)-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)-hexan-2-ol emulsifiable concentrate

[0046] Weigh (RS)-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)-hexan-2-ol original drug 8kg, emulsifier 10kg , the solvent was added to 100 liters, stirred evenly, and divided into 40ml / bottles. When in use, exactly 20kg is allocated to each bottle (one bag of quicklime essence available in the market).

Embodiment 3

[0047] Example 3: Preparation of (RS)-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)-hexan-2-ol suspension

[0048] Weigh (RS)-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)-hexan-2-ol original drug 8kg, and suitable auxiliary Mix the agent and water to 100 liters, ball mill using conventional methods, and pack into 40ml / bottles. When in use, exactly 20kg is allocated to each bottle (one bag of quicklime essence available in the market).

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Abstract

The invention relates to application of (RS)-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazole-1-radical)-hexyl-2-alcohol to preparation of a silkworm disease treating medicament. Silkworm diseases refer to silkworm fungus diseases, including various muscardines and aspergillus diseases. An obtained medicament is generally of a solution dosage form, and the acting concentration of the medicament is 50-200 ppm. Due to the application, novel application of the (RS)-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazole-1-radical)-hexyl-2-alcohol to the field of silkworm disease treating medicaments is expanded, good prevention and controlling effects on the silkworm fungus diseases are achieved, and the blank of an antifungal silkworm medicament is filled.

Description

technical field [0001] The purposes of (RS)-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)-hexan-2-alcohol of the present invention, especially relate to (RS Use of )-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)-hexan-2-ol in the preparation of silkworm medicine; belongs to the field of veterinary medicine Silkworm medicine sequence. Background technique [0002] Bombyx mori fungal disease is listed as a second-class animal disease by the Ministry of Agriculture. Its harm has plagued the sericulture industry and often caused heavy losses. It is one of the main diseases that affect the yield and cocoon quality of the sericulture industry. Over the years, people have developed a variety of disinfectants for silkworms. Through comprehensive measures such as strengthening the disinfection of silkworm rooms, silkworm bodies and silkworm seats, mulberry leaf surface disinfection, and improving feeding management, although effective, they are always unsatisfactory. So far A...

Claims

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Application Information

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IPC IPC(8): A61K31/4196A61P31/10
Inventor 陈俊骥周元铎仲伟荣吕广祥
Owner 周元铎
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