Immature bitter orange or bitter orange total flavonoid extract decocted and extracted by water and its purpose

Abstract

The invention relates to an immature bitter orange or bitter organe total flavonoid extract. The preparation method comprises the following steps: immature bitter orange or bitter orange is weighted, sliced into decoction pieces or crushing, 4-15 times water is added, decocted 1-3 times, wherein each decoction and extraction time is 1-3 hours, decocted fluid is merged and filtrated, a filtrate is passed through a processed non-polar macroporous resin, impurities are successively eluted by using water and less than 20% of ethanol and removed, and eluted by 25-90% of ethanol and 0.5-2% of sodium hydroxide, an ethanol eluate is collected and carried out pressure reduction and condensation to obtain a fluid extract with relative density of 1.20-1.40 (50 DEG C-70 DEG C), pressure reduction and drying are carried out, wherein the drying temperature is 60-80 DEG C, crushed to obtain the immature bitter orange or bitter orange total flavonoid extract. The immature bitter orange or bitter orange total flavonoid extract can be used for preparing medicines for treating stomach and intestine functional dyspepsia, epigastric pain, abdominal distension, apocleisis, eructation, nausea, emesis and emesis caused by chemotherapeutics or other reasons, and the extract of the invention can be prepared to medicinally acceptable drugs.

Description

technical field [0001] The invention relates to a decocted and extracted total flavonoid extract of Fructus Aurantii or Fructus Fructus Fructus and its application. Background technique [0002] Functional dyspepsia (FD) is a common and frequently-occurring disease. Also known as gastric insufficiency, or gastric motility disorder. Is a common clinical syndrome, foreign statistics show that 1 / 3 of the population suffered from FD, accounting for 20% to 30% of outpatients. Domestically, it accounts for about 50% of digestive system outpatients, and occurs in 20% to 40% of normal people. In addition, more than 80% of cancer patients will cause vomiting after chemotherapy. The main anti-vomiting drugs are Metoclon and Zofran, but chemical drugs are accompanied by fatigue, dizziness, headache, and even neck and back muscle pain. Cramp symptoms. [0003] At present, Western medicine mainly treats modinline, cisapride, mosapride, etc.; however, with the extensive use of them,...

AI Technical Summary

Problems solved by technology

However, Citrus aurantium and Fructus aurantium are only used in a small amount in clinical formulas and Chinese patent medicine preparations, and a large amount of resources have not been widely used. Their natural effects of breaking Qi and eliminating stagnation may not be fully exploited in the similarity with modern gastric motility-promoting drugs.

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