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Magnetic tweezers probe based on optical fiber

An optical fiber and magnetic tweezers technology, applied in the field of magnetic tweezers probes, can solve the problems of small number of coils, weak magnetic field, poor biomolecular capture and manipulation flexibility, etc., and achieves the effect of small size

Inactive Publication Date: 2014-01-29
ANHUI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the magnetic tweezers probe made of flat micro-coils has achieved miniaturization, the number of rewinding coils is small, the magnetic field generated is not strong, the probe cannot move, and the flexibility for capturing and manipulating biomolecules is not good.

Method used

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  • Magnetic tweezers probe based on optical fiber
  • Magnetic tweezers probe based on optical fiber

Examples

Experimental program
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Embodiment Construction

[0024] see figure 1 , figure 2 In this embodiment, the needle core is composed of an optical fiber 1 with a magnetic core layer 2 on the surface, and the light beam transmitted by the optical fiber can be emitted from the front end of the needle core; an inner heat-conducting insulating layer 3, a micro Helical coil 4 , outer thermally conductive insulating layer 5 and shielding layer 6 .

[0025] In specific implementation, the corresponding structural settings also include:

[0026] The optical fiber 1 is a single-core optical fiber or a multi-core optical fiber. The single-core optical fiber can realize the collimated output of the laser beam from the front surface of the needle core, and perform optical operations on biomolecules; The output of two optical fiber cores can form the force of optical tweezers on biomolecules, and form the operation of complex biomolecules with the action of magnetic tweezers;

[0027] The front section of the needle core is set as a penci...

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Abstract

The invention discloses a magnetic tweezers probe based on an optical fiber. The magnetic tweezers probe is characterized in that: a probe core is constructed by an optical fiber of which the surface is provided with a magnetic core layer; light beams transmitted by the optical fiber can be emitted from the front end face of the probe core; and the periphery of the probe core is provided with an inner heat conducting insulating layer, a micro spiral coil, an outer heat conducting insulating layer and a shield layer from inside to outside in sequence. The magnetic tweezers probe has the advantages of small size, no need of any complex radiating structure, adjustable size and direction of a generated magnetic field, flexible movement and realization of the functions of capturing, controlling and optically operating biomolecules.

Description

technical field [0001] The invention relates to a magnetic tweezers probe, in particular to an optical fiber-based magnetic tweezers probe. Background technique [0002] Magnetic tweezers is a technology that uses an external magnetic field to control micro- or nano-sized magnetic particles for micro-manipulation. It was first introduced into the field of molecular biology by Crick F.H.C and others since 1949 [Crick F.H.C, Hughes A.F.W, The physical properties of cytoplasm: a study by means of the magnetic particle method, Exp. Cell. Res. 1:37-80, 1949]. Biological manipulation of biomacromolecules using magnetic tweezers can be used to study intracellular properties, determine the mechanical properties of individual cells, and batch separate cells labeled with magnetic beads. Because magnetic tweezers do not cause damage to cells and biological macromolecules, they have become one of the main technologies for biological manipulation. Compared with molecular manipulation t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/48
Inventor 徐峰俞本立曹志刚朱军吕卫卫冯飞武为江
Owner ANHUI UNIVERSITY
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