Traditional Chinese medicine compound extract for treating postmenopausal osteoporosis and preparation method thereof

A technology for osteoporosis and extracts, which is applied in the field of preparation and treatment of menopause involving the extracts, and can solve the problems of increasing the prevalence of ovarian cancer, endometrial cancer, other adverse reactions, and limiting applications

Inactive Publication Date: 2012-03-07
张宁
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the long-term single use of estrogen increases the prevalence of ovarian cancer, breast cancer, endometrial cancer and other adverse reactions, which limits its application

Method used

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  • Traditional Chinese medicine compound extract for treating postmenopausal osteoporosis and preparation method thereof
  • Traditional Chinese medicine compound extract for treating postmenopausal osteoporosis and preparation method thereof
  • Traditional Chinese medicine compound extract for treating postmenopausal osteoporosis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1 (TQW is to the influence of ovariectomized osteoporosis model rat)

[0045] The ovariectomized osteoporosis rat model is an internationally recognized classic animal model for simulating postmenopausal osteoporosis in women. This example uses this model to verify the effect of TQW on treating postmenopausal osteoporosis in women.

[0046] 1 Materials and methods

[0047] 1.1 Materials

[0048] Clean-grade 7-month-old Wistar rats, female, weighing 350±20 g, were purchased from the GLP Center of Heilongjiang University of Traditional Chinese Medicine.

[0049] TQW suspension: suspend TQW in distilled water, and the ig dose is 15 mg / kg.

[0050] Nilestriol suspension (Nilestrdiol): nilestriol (purchased from Hualian Pharmaceutical Factory of Shanghai Pharmaceutical Group, National Drug Approval: H3102164), suspended in distilled water, ig 0.5 mg / kg.

[0051] 1.2 Method

[0052] 1.2.1 Establishment of Ovariectomized Rat Osteoporosis Model

[0053] After an...

Embodiment 2

[0088] Embodiment 2 (preparation of tablet)

[0089] In parts by weight, take 5-9 parts of TQW, add 1-2 parts of talcum powder, 1-2 parts of starch, 1-2 parts of carboxymethyl starch sodium, spray 95% ethanol to moisten, wet granulate, dry, add 0.5-1% magnesium stearate, mixed evenly, and compressed into tablets; adding 15% Opadry coating solution for coating, and then coating with 7% weight gain to obtain film-coated tablets.

Embodiment 3

[0090] Embodiment 3 (preparation of capsule)

[0091] In parts by weight, take 8-9 parts of TQW, add 1-2 parts of talcum powder, spray into 95% ethanol to moisten, wet granulate, dry, add 0.5-1% magnesium stearate, mix evenly, and pack into capsules agent.

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PUM

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Abstract

The invention relates to traditional Chinese medicine compound extract for treating postmenopausal osteoporosis. The traditional Chinese medicine compound extract for treating postmenopausal osteoporosis is prepared from eleven traditional Chinese medicines of patrinia villosa juss., densefruit pittany root-bark, hairyvein agrimony, radix bupleuri, common cnidium fruit, rhodiola rosea, cassia seed, semen platycladi, wild buckwheat, oriental waterplantain rhizome and licorice. The traditional Chinese medicine compound extract for treating postmenopausal osteoporosis is prepared through a carbon dioxide supercritical extraction technology and a macroporous absorption resin enrichment technology according to certain technological parameters. The traditional Chinese medicine compound extract has obvious effects of treating postmenopausal osteoporosis, and can be safely utilized for preparation of drug preparations and health-care foods, wherein the drug preparations and health-care foods have postmenopausal osteoporosis treatment effects.

Description

technical field [0001] The present invention relates to a compound extract of traditional Chinese medicine, in particular to a method of using carbon dioxide supercritical extraction technology and macroporous adsorption resin enrichment technology to extract Patrinia dahliae, D. chinensis, Agrimony, Bupleurum, Fructus Cnidii, Red Sedum, Cassia, Boziren, Golden Buckwheat, Alisma and Licorice are the extracts, which have obvious effects on treating postmenopausal osteoporosis. The invention also relates to the application of the extract in the preparation of pharmaceutical preparations and health food for treating postmenopausal osteoporosis. Background technique [0002] Postmenopausal osteoporosis refers to a systemic skeletal disease characterized by low bone mass and microstructural degeneration of bone tissue in postmenopausal women due to the decline of ovarian function and estrogen level. The main clinical manifestations of osteoporosis are pain, short stature, and fr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/884A23L1/29A61P19/10A23L33/00
Inventor 张丹丹朴成玉任燕冬刘海洋张春蕾张宁王发善
Owner 张宁
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