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Traditional Chinese medicine composition for preventing and treating lung injury due to radioactive radon and daughters thereof

A technology for lung injury and composition, which is applied in the field of traditional Chinese medicine compositions for preventing and treating lung injury caused by radioactive radon and its progeny, and can solve the problem of no commercially available drugs for preventing and treating radon-induced lung injury.

Inactive Publication Date: 2012-02-22
GENERAL HOSPITAL OF THE SECOND ARTILLERY OF CHINESE PLA
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0010] At present, there are no commercially available drugs for the prevention and treatment of radon-induced lung injury (including pneumonia, pulmonary fibrosis and lung cancer) at home and abroad.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0025] The radon lung injury protective agent developed by the present invention uses method and experimental result as follows:

[0026] 1. Animal grouping and radon exposure:

[0027] 18 clean-grade male SD rats, weighing about (150±20) g. They were randomly divided into control group, radon exposure group and radon lung injury protection agent group, with 6 rats in each group. Put the rats in radon exposure group and radon lung injury protection agent group into HD-3 multifunctional ecological radon chamber, the radon concentration in the radon chamber environment is 40000Bq / m3, and the total exposure time of each rat is 1890h, that is, 120 working level month (WLM), the dose rate is 0.056WLM / h. The rats in the radon lung injury protective agent group were given 5ml (1000g / L) radon lung injury protective agent by intragastric administration once a day, and the radon exposure group were given 5ml normal saline intragastric administration once a day; 50Bq / m3 of room temper...

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Abstract

The invention relates to a traditional Chinese medicine composition for preventing and treating lung injury due to radioactive radon and daughters thereof, that is a radon lung injury protective agent, and particularly is to develop a radon lung injury protective agent which can prevent and treat pneumonia, pulmonary fibrosis, and lung cancer caused by high radon exposure. The invention comprises traditional Chinese medicines which can tonify qi and nourish yin, clear heat and invigorate blood, strengthen body resistance and remove toxin, can reduce lung injury caused by high radon exposure, can be used for the prevention and treatment of pneumonia, pulmonary fibrosis, and lung cancer caused by radioactive radon and daughters thereof.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for preventing and treating lung damage caused by radioactive radon and its progeny, that is, a protective agent for radon lung damage, and specifically develops a drug that can prevent and treat pneumonia, pulmonary fibrosis and lung cancer caused by high radon exposure. Radon Lung Damage Protectant. Background technique [0002] In the 15th century, in the Schneeberg mine in Germany, miners were prone to suffer from a high-mortality lung disease called "Schneeberg" lung disease. In the 1880s, this disease was identified as lung cancer. In 1924, it was proposed that lung cancer in miners May be related to radon exposure. Since then, a large number of epidemiological investigations have shown that in a high radon environment, the gamma radiation of radon daughters can increase the risk of lung cancer. Sacomano et al. calculated that when the cumulative exposure of radon and its proge...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61P11/00A61P35/00
Inventor 江其生张蓉李志韧
Owner GENERAL HOSPITAL OF THE SECOND ARTILLERY OF CHINESE PLA
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