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Device and microchip for sorting particles

A microparticle and microchip technology, which is applied in biochemical equipment and methods, material analysis by electromagnetic means, individual particle analysis, etc. The effect of eliminating cross-contamination

Inactive Publication Date: 2012-01-11
SONY CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, as in a conventional flow cytometer (cell sorter), it is difficult to increase the fine particles and flow velocity and sorting rate, and it is difficult to measure cell count at high speed (for example, several thousand to tens of thousands of cells per second). characteristics and sorting

Method used

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  • Device and microchip for sorting particles
  • Device and microchip for sorting particles
  • Device and microchip for sorting particles

Examples

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Embodiment Construction

[0045] The present invention provides a microparticle sorting apparatus, which includes: a microchip provided with a flow path through which a liquid containing microparticles flows and an orifice through which the liquid flowing through the flow path is discharged into a space outside the microchip. an oscillating element for converting the liquid into droplets at the orifice and discharging the droplets; a charge device for adding charge to the discharged droplets; an optical detection device for upstream of the orifice in the direction of liquid delivery relative to the orifice , detecting the optical properties of microparticles flowing through the flow path; a pair of electrodes, which are arranged to face each other while sandwiching a moving droplet therebetween along the moving direction of the droplet discharged into the off-chip space and two or more containers, which collect the liquid droplets passing between the paired electrodes, wherein the width and depth of the...

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Abstract

Disclosed is a sorting device capable of high-speed analysis and sorting with safety, high speed, and low cost by preventing cross-contamination between samples, contamination of samples, biohazard to the users, obviating the needs for an expensive flow cell and an expensive orifice part and for fine adjustment of the flow cell and the orifice. The device (A) for sorting particles is provided with a microchip (1) in which a flow channel (11) through which liquid containing particles is flown and an orifice (12) for discharging the liquid flowing through the flow channel (11) to a space outside the chip are provided, a vibratory element (2) for making and ejecting a droplet of the liquid at the orifice (12), a charging means for giving charge to the ejected droplet (D), an optical detecting means (3) for detecting an optical characteristic of the particles flowing through the flow channel (11), paired electrodes (4,4) arranged along the direction of movement of the ejected droplet (D) and opposed with the moving droplet (D) therebetween, and two or more vessels for collecting the droplet (D) passing between the paired electrodes (4, 4).

Description

technical field [0001] The invention relates to a device and a microchip for sorting microparticles. More specifically, the present invention relates to a microparticle sorting apparatus or the like that detects, within a microchip, characteristics of microparticles flowing through a flow path formed in the chip, discharges liquid droplets containing the microparticles to the outside of the chip, and based on The characteristics of the detected microparticles control the direction of movement of the droplets for sorting. Background technique [0002] Traditionally, in order to identify the properties of microparticles such as biologically relevant microparticles (such as cells, microorganisms, liposomes) or synthetic particles (such as latex particles, gel particles, or industrial particles), devices have been utilized that combine the microparticles The dispersed liquid is introduced into the flow path, and the characteristics of the microparticles that have been introduce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N15/14B01J19/00C12M1/34G01N37/00
CPCG01N2015/1488G01N15/1484B01L2400/0433B01L3/502746B01L2400/0487B01L3/502776B01L3/0268G01N15/1459B01L3/502761G01N2015/1006Y10T137/8158G01N15/1492G01N15/1404G01N15/1434G01N27/44791G01N15/149G01N15/1409G01N2015/1028G01N2015/1481G01N2015/1422G01N27/44743
Inventor 篠田昌孝
Owner SONY CORP
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