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Application of total flavonoids from coriander root to prepare hypoglycemic drugs

A technology for total flavonoids and hypoglycemia, which is applied in directions such as drug combinations, pharmaceutical formulations, and plant raw materials to achieve the effects of low production cost, stable quality and simple method.

Active Publication Date: 2011-12-28
西藏自治区高原生物研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the published methods for the development and utilization of coriander root, there is no report on the hypoglycemic effect of the total flavonoids of coriander root

Method used

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  • Application of total flavonoids from coriander root to prepare hypoglycemic drugs
  • Application of total flavonoids from coriander root to prepare hypoglycemic drugs

Examples

Experimental program
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Effect test

Embodiment 1

[0038] Using method A, take the sun-dried coriander root and crush it to 100 mesh, boil it with 5 times the volume of distilled water, and slowly add NaOH while stirring continuously after boiling to adjust the pH of the solution to 10. Continue to keep boiling for 20min. While hot, use four layers of gauze pads to carry out suction filtration on the Buchner funnel, and filter the filtrate again with medium-speed filter paper after the suction filtration. Collect the filtrate. The filter residue was decocted again with 5 times the volume of distilled water for 20 minutes, suction filtered and filtered, and the filter residue was repeatedly extracted 3 times in this way, and the filtrates were combined. Heat the filtrate to 60°C, slowly add concentrated hydrochloric acid, adjust the pH of the solution to 4, stir evenly, let stand for 24 hours, and filter with suction to collect the precipitate. The precipitate was washed with a large amount of distilled water until the pH was...

Embodiment 2

[0040] Using method A, take the sun-dried coriander root and crush it to 40 mesh, boil it with 15 times the volume of distilled water, and slowly add lime milk while stirring continuously after boiling, and adjust the pH of the solution to 9. Continue to keep boiling for 60min. While hot, use four layers of gauze pads to carry out suction filtration on the Buchner funnel, and filter the filtrate again with medium-speed filter paper after the suction filtration. Collect the filtrate. The filter residue was decocted again with 15 times the volume of distilled water for 60 minutes, suction filtered and filtered, and the filter residue was extracted once more in this way, and the filtrates were combined. Heat the filtrate to 80°C, slowly add concentrated hydrochloric acid, adjust the pH of the solution to 4, stir evenly, let stand for 24 hours, and filter with suction to collect the precipitate. The precipitate was washed with a large amount of distilled water until the pH was 7...

Embodiment 3

[0042]Using method A, take the sun-dried coriander root and crush it to 200 mesh, boil it with 10 times the volume of distilled water, and slowly add milk of lime while stirring continuously after boiling, and adjust the pH of the solution to 8. Continue to keep boiling for 40min. While hot, use four layers of gauze pads to carry out suction filtration on the Buchner funnel, and filter the filtrate again with medium-speed filter paper after the suction filtration. Collect the filtrate. The filter residue was decocted again with 5 times the volume of distilled water for 40 minutes, suction filtered and filtered, and the filter residue was extracted twice in this way, and the filtrate was combined. Heat the filtrate to 70°C, slowly add concentrated hydrochloric acid, adjust the pH of the solution to 4, stir evenly, let stand for 24 hours, and then filter with suction to collect the precipitate. The precipitate was washed with a large amount of distilled water until the pH was ...

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Abstract

The invention relates to application of total flavonoids of lilac daphne root extracted from a lilac daphne plant to preparation of a medicament for reducing blood sugar. The total flavonoids of lilac daphne root, which is disclosed by the invention, respectively represents remarkable activity of reducing blood sugar at each dosage; and the total flavonoids of lilac daphne root can be used for preparing a medicament or health-card food for preventing or treating hyperglycemia symptom.

Description

technical field [0001] The invention relates to the use of total flavonoids extracted from daphne root plants to prepare hypoglycemic drugs, and belongs to the field of medicinal natural products. Background technique [0002] A large number of epidemiological studies have shown that abnormally elevated blood sugar is a risk factor for diabetes. Diabetes is a common endocrine and metabolic disease and the third major disease that endangers human health after cardiovascular disease and cancer. Because diabetes has the characteristics of high prevalence rate, disability rate and high complication rate, it has become one of the diseases that the medical field has paid much attention to and paid more attention to. [0003] Most of the current hypoglycemic drugs are Western medicines or large compound prescriptions of traditional Chinese medicines. Western medicines (including injections and oral hypoglycemic drugs) have strong and rapid effects. Excessive doses cause hypoglycemi...

Claims

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Application Information

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IPC IPC(8): A61K36/83A61P3/10
Inventor 蒋思萍高平
Owner 西藏自治区高原生物研究所
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