Fast dissolving oral tablets and method for production thereof
An oral tablet, rapid technology, applied in the direction of pill delivery, pharmaceutical formula, medical preparations of non-active ingredients, etc., can solve the problems of inapplicability, abnormal size of tablets, etc.
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Embodiment 1
[0039] A general tablet with a total tablet weight of 100 mg and a hardness of 7 kp was obtained by using 90 mg D-mannitol as a sugar alcohol, 2.5 mg PVR k-30 as a binder, 5 mg cetyl alcohol as a supercritical fluid-soluble substance, and 2.5 mg SiO 2 Made as a lubricant. And then, cetyl alcohol as a supercritical fluid-soluble substance was purified and extracted by contacting the tablet with supercritical fluid at a temperature of 40° C. and a pressure of 80 bar for 30 minutes to produce a fast-dissolving tablet with micropores.
Embodiment 2
[0041] A general tablet with a total tablet weight of 100 mg and a hardness of 7 kp was obtained by using 90 mg D-mannitol as a sugar alcohol, 2.5 mg PVR k-30 as a binder, 5 mg cetyl alcohol as a supercritical fluid-soluble substance, and 2.5 mg SiO 2 Made as a lubricant. And then, cetyl alcohol as a supercritical fluid-soluble substance was purified and extracted by contacting the tablet with supercritical fluid at a temperature of 40° C. and a pressure of 80 bar for 30 minutes to produce a fast-dissolving tablet with micropores. The extraction rate of the supercritical fluid-soluble matter is 50.4%.
Embodiment 3
[0043] The same method as in Example 2 was used to produce fast dissolving tablets, except that the generic tablet in Example 2 above was contacted with supercritical fluid at a temperature of 40° C. and a pressure of 80 bar for 90 minutes. The extraction rate of the supercritical fluid-soluble matter is 101.0%.
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