Preparation method of notopterygium root spray of nine ingredients

Abstract

The invention provides a preparation method of a notopterygium root spray of nine ingredients, relating to a preparation method of a traditional Chinese medicine spray. The notopterygium root spray of nine ingredients is composed of notopterygium root, divaricate saposhnikovia root, Chinese atractylodes, asarum herb, chuanxiong rhizome, angelia, baical skullcap root, licorice and rehmannia root. The preparation method comprises the following steps of: extracting volatile oils from the notopterygium root, the divaricate saposhnikovia root, the Chinese atractylodes, the asarum herb, the chuanxiong rhizome and the angelica; performing ultrasonic extraction on the dregs after extraction, the baical skullcap root, the licorice and the rehmannia root, filtering after extraction; concentrating the obtained filtrate, adding ethanol, standing and filtering; and concentrating the filtrate, recovering the ethanol, adding the volatile oils, a surfactant, an essence and a preservative to the concentrated solution, mixing evenly, supplementing distilled water, filtering, subpackaging and sterilizing. The preparation method provided by the invention has the characteristics of short extraction time, high yield, no need of heating, and the like, saves the production time, improves the extraction rate, avoids degradation of thermal instable ingredients, is favorable to full utilization of medicinal materials, and saves energy and cost.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine spray, in particular to a preparation method of a nine-flavor notopterygium spray. Background technique [0002] Jiuwei Qianghuo is composed of Qianghuo, Fangfeng, Cangzhu, Asarum, Chuanxiong, Baizhi, Scutellaria, Licorice, and Dihuang. It has the effects of relieving the exterior, dispersing cold, and dehumidifying. The combination of nine medicinal materials can not only cure wind-cold and damp pathogens, but also coordinate the exterior and interior. Together, they form a medicine for sweating and dampness, and at the same time clearing internal heat. It is a classic prescription for treating wind-cold and cold. [0003] The main documents that have publicly recorded Jiuwei Qianghuo include: Jiuwei Qianghuo Oral Liquid, Jiuwei Qianghuo Pills and Jiuwei Qianghuo Granules, which are included in the first part of the Pharmacopoeia of the People's Republic of China; the appl...

AI Technical Summary

Problems solved by technology

However, the preparation methods of Jiuwei notopterygium preparations disclosed in the Pharmacopoeia and the above invention patents are all prepared by immersion, percolation extraction, steam distillation to extract the volatile oil in the medicinal materials, decoction to extract water-soluble components, and concentration. The process is relatively rough, and the extraction method is not scientific and rigorous, resulting in low extraction rate and serious waste of Chinese medicinal materials. Some active ingredients are easily degraded by heat, which increases production costs and affects product quality.

Moreover, Jiuwei notopterygium is made into oral preparations. After oral administration, these preparations must be absorbed through the gastrointestinal tract, which cannot avoid the first-pass effect of the liver, resulting in poor drug absorption and low oral bioavailability.

In addition, during the preparation or administration of these oral preparations, the active ingredients of the volatile oil of the drug will be lost, which will affect the efficacy of the drug.