Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Beta-defensin 15 of specific antibacterial peptides of rat epididymis and application thereof

A technology of use and gene, applied in the field of rat epididymal specific antimicrobial peptide β-defensins and its use, can solve the problem of less β-defensins and the like

Active Publication Date: 2013-10-09
苏州中科细胞转化研究院
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, in addition to immune defense, they may also play a role in maintaining normal reproductive processes, such as participating in the maturation and protection of sperm, and it has been proven that there are very few β-defensins involved in this process

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Beta-defensin 15 of specific antibacterial peptides of rat epididymis and application thereof
  • Beta-defensin 15 of specific antibacterial peptides of rat epididymis and application thereof
  • Beta-defensin 15 of specific antibacterial peptides of rat epididymis and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0027] This application provides the rat Defb15 gene or its homologous gene, or the amino acid sequence encoded by the Defb15 gene or its homologous gene in the preparation of drugs for regulating male fertility, the development of male contraceptives, the preparation of diagnosis and treatment of male infertility Use in medicines for infertility and anti-genital tract infections.

[0028] The nucleotide sequence (NM_001037520) and its amino acid sequence (NP_001032609.1) of the rat Defbl5 gene are available from Genebank.

[0029] Homologous genes in this paper refer to interspecific homologous genes, some homologous genes originating from a common ancestral gene in different species, and these genes usually maintain the same or similar functions. According to the results of BLAST on the NCBI website, the homologous genes of rat Defb15 include human DEFB106B (NP_001035794.1) and mouse Defb15 (NP_631968.1).

[0030] Alternatively, homologous genes of the present application m...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
molecular weightaaaaaaaaaa
Login to View More

Abstract

The invention relates to beta-defensin 15 of specific antibacterial peptides of rat epididymis and application thereof, in particular to Defb15 genes of rats or orthologous genes thereof or application of amino acid sequences of the Defb15 genes or the orthologous genes thereof in the preparation of medicines for regulating and controlling male fertility, the development of male contraceptive medicines and the preparation of medicines for diagnosing and treating male infertility and resisting genital tract infection. The invention also relates to a medicinal composition containing the genes or the amino acid sequences.

Description

technical field [0001] This application relates to epididymis-specific antimicrobial peptide β-defensin 15 (defensin) and its application. Background technique [0002] The epididymis is a highly coiled tube that connects the testis and the vas deferens. It is the place for sperm maturation, protection, transportation and storage, and plays an important role in the reproduction of male mammals. Morphologically, the epididymis is roughly divided into four segments: Initial segment, Caput, Corpus, and Cauda. Sperm released from the seminiferous tubules of the testis are functionally immature and need to undergo a series of complex structural and functional changes in the epididymis to acquire motility and potential fertilization ability to reach maturity[1-4]. It is derived from the interaction of spermatozoa with the luminal fluid of the epididymis. Epididymis intima epithelial cells can secrete a variety of proteins, some of which can be incorporated or bound to the surfac...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/17A61K48/00A61K39/395A61K31/713A61P15/16A61P15/08A61P15/00A61P31/04A61P31/10
Inventor 张永莲赵越刁华
Owner 苏州中科细胞转化研究院
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com