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Fused heterocyclic compound

A compound and heterocyclic technology, applied in the field of platelet aggregation inhibitors, pharmaceutical compositions for inhibiting platelet aggregation, heterocyclic compounds or their pharmaceutically acceptable salts, can solve problems such as application limitations and low efficacy

Inactive Publication Date: 2011-08-10
LG LIFE SCI LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] Currently, the use of known antiplatelet and anticoagulant agents is limited due to low potency and significant bleeding problems

Method used

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  • Fused heterocyclic compound
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Examples

Experimental program
Comparison scheme
Effect test

preparation example 1-1-1

[0739] 2,4-Dichloro-6-propyl-thieno[2,3-d]pyrimidine

[0740]

[0741] The synthesis was performed according to known methods (WO 2006 / 079916).

preparation example 1-1-2

[0743] 3-Trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

[0744]

[0745] Synthesis was performed according to a known method (Organic Letters 2005, 7(6), 1039-1042).

preparation example 1-1-3

[0747] 7-(2-Chloro-6-propyl-thieno[2,3-d]pyrimidin-4-yl)-3-trifluoromethyl-5,6,7,8-tetrahydro-[1,2 ,4]triazolo[4,3-a]pyrazine

[0748]

[0749] The compound (225 mg, 0.91 mmol) obtained in Preparation Example 1-1-1 and the compound (250 mg, 1.09 mmol) obtained in Preparation Example 1-1-2 were diluted in N,N-dimethylformamide (5 mL). mmol), and diisopropylethylamine (353 mg, 2.73 mmol) was added thereto, and the mixture was stirred for 16 hours. The reaction mixture was distilled under reduced pressure, diluted with dichloromethane, and washed with water. The organic layer was dried over anhydrous magnesium sulfate, distilled under reduced pressure, then solidified, and washed with diethyl ether to obtain the title compound (289 mg, 79%).

[0750] 1 H NMR (400MHz, CDCl 3 );

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Abstract

The present invention relates to a fused heterocyclic compound having the Formula 1, which is useful as a platelet aggregation inhibitor, a method for preparing the same, and a pharmaceutical composition for inhibiting platelet aggregation comprising the same.

Description

technical field [0001] The present invention relates to a fused heterocyclic compound having the following formula 1 or a pharmaceutically acceptable salt thereof, which is useful as a platelet aggregation inhibitor. [0002] [Formula 1] [0003] [0004] wherein P, Q, R, T and X are as defined herein. [0005] The present invention also relates to a process for preparing a fused heterocyclic compound having Formula 1 or a pharmaceutically acceptable salt thereof. [0006] The present invention also relates to a pharmaceutical composition for inhibiting platelet aggregation, comprising the fused heterocyclic compound having formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient. Background technique [0007] Platelets have long been considered essential for hemostasis. Hemostasis is the body's protective process of stopping bleeding from damaged blood vessels. However, abnormal hemostasis in blood vessels may produce blood clots. Platelets ar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D495/04
CPCC07D519/00C07D495/04A61P7/00A61P7/02A61P7/04A61P9/00A61P9/06A61P9/10A61P11/08A61P13/12A61P43/00C07D403/04
Inventor 李昌锡李太熙尹淑卿崔增洵张容溱金成昱张惠卿朴美贞金泰勋安英夏朴喜东朴贤静林东哲李周莲李承学朴完洙吴英秀
Owner LG LIFE SCI LTD
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