Phosphorus substituent group-containing quinoline compound and preparation method of quinoline compound as well as pharmaceutical composition containing quinoline compound and application of pharmaceutical composition

Abstract

The invention provides a phosphorus substituent group-containing quinoline compound as shown in a formula (I). Simultaneously, the invention also discloses a preparation method and an application of the compound as well as a medicament containing the phosphorus substituent group-containing quinoline compound. The compound is an inhibitor of protein kinase, can be used for treating diseases caused by abnormal protein kinase activity, such as tumour and the like.

Description

A quinoline compound containing a phosphorus substituent and its preparation method, as well as a pharmaceutical composition containing the compound and its application technical field The invention relates to the fields of organic chemistry and medicinal chemistry, in particular to a quinoline compound containing a phosphorus substituent, a preparation method thereof, a pharmaceutical composition containing the compound and an application thereof. Background technique Protein kinases are a class of phosphotransferases, whose function is to transfer the γ-phosphate group of ATP to specific amino acid residues of the substrate, phosphorylate proteins, and exert their physiological and biochemical functions. Protein kinase is an important class of kinases. It has two main functions in signal transduction: one is to regulate the activity of proteins through phosphorylation; cellular response. The abnormality of protein kinase activity is not only closely related to tumor pr...

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Problems solved by technology

There is evidence that IR is also an effective anti-cancer target, but because the inhibition of IR has the risk of increasing blood sugar, IR inhibitors need to find a balance between benefit and safety risk when used in anti-cancer

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