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Composition for increasing bone mineral density and preparation method thereof

A technology for increasing bone density and composition, applied in the field of the composition for increasing bone density and its preparation, can solve the problems of hunched over, bone calcium loss, vertebral compression fracture, etc., and achieves the promotion of utilization and the increase of bone calcium level. , the effect of alleviating osteoporosis

Active Publication Date: 2013-02-27
BEIJING TONGRENTANG HEALTH PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term insufficient calcium intake requires continuous extraction of "deposits" from the bone bank to ensure a constant blood calcium. Bone calcium is constantly lost. Although there is no performance when young, osteoporosis will occur earlier in old age, leading to spinal cord damage. Compression fractures, causing hunched over

Method used

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  • Composition for increasing bone mineral density and preparation method thereof
  • Composition for increasing bone mineral density and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Raw materials: calcium carbonate 180kg, D-glucosamine hydrochloride 23kg, collagen 15kg, polyvinylpyrrolidone 5kg, magnesium stearate 2kg.

[0033] The preparation method of capsule:

[0034] 1) Calcium carbonate, D-glucosamine hydrochloride, collagen, polyvinylpyrrolidone, and magnesium stearate are sent to the clean area after removing the outer packaging. Take formula amount of calcium carbonate, D-glucosamine hydrochloride, and collagen respectively pass through a 100-mesh sieve in a high-efficiency powder sieving machine, and mix in a three-dimensional swing mixer for 20 minutes to obtain a mixed powder.

[0035] 2) Dissolving polyvinylpyrrolidone in purified water to prepare an 8% aqueous solution as a binder.

[0036] 3) Put the mixed powder into a wet granulator, add an appropriate amount of the above binder to make a soft material, add water appropriately, and granulate with a 30-mesh sieve to obtain wet granules. The wet granules were dried in a spray drying...

Embodiment 2

[0041] Raw materials: calcium carbonate 360kg, D-glucosamine hydrochloride 46kg, collagen 30kg, polyvinylpyrrolidone 10kg, magnesium stearate 4kg.

[0042] The preparation method of capsule:

[0043] 1) Calcium carbonate, D-glucosamine hydrochloride, collagen, polyvinylpyrrolidone, and magnesium stearate are sent to the clean area after removing the outer packaging. Take formula amount of calcium carbonate, D-glucosamine hydrochloride, and collagen respectively pass through 80-mesh sieve in a high-efficiency powder sieving machine, and mix in a three-dimensional swing mixer for 30 minutes to obtain a mixed powder.

[0044] 2) Dissolving polyvinylpyrrolidone in purified water to prepare a 10% aqueous solution as a binder.

[0045] 3) Put the mixed powder into a wet granulator, add an appropriate amount of the above binder to make a soft material, add water appropriately, and granulate with a 20-mesh sieve to obtain wet granules. The wet granules were dried in a spray drying g...

Embodiment 3

[0050]Raw materials: calcium carbonate 540kg, D-glucosamine hydrochloride 69kg, collagen 45kg, polyvinylpyrrolidone 15kg, magnesium stearate 6kg.

[0051] The preparation method of capsule:

[0052] 1) Calcium carbonate, D-glucosamine hydrochloride, collagen, polyvinylpyrrolidone, and magnesium stearate are sent to the clean area after removing the outer packaging. Take formula amount of calcium carbonate, D-glucosamine hydrochloride, and collagen respectively pass through 60-mesh sieve in a high-efficiency powder sieving machine, and mix in a three-dimensional swing mixer for 40 minutes to obtain a mixed powder.

[0053] 2) Polyvinylpyrrolidone was dissolved in purified water to make a 12% aqueous solution as a binder.

[0054] 3) Put the mixed powder into a wet granulator, add an appropriate amount of the above binder to make a soft material, add water appropriately, and granulate with a 10-mesh sieve to obtain wet granules. The wet granules were dried in a spray drying gr...

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Abstract

The invention provides a composition for increasing the bone mineral density. The composition mainly comprises the following raw materials in parts by weight: 180-540 percent of calcium carbonate, 23-69 percent of D-glucosamine hydrochloride and 15-45 percent of collagen. The invention also provides a preparation method of the composition. The raw materials adopted by the composition for increasing the bone mineral density have no toxic and side effects, health and safety, has the effects of promoting calcium absorption and relieving osteoporosis and can safely and effectively supplement calcium of the human body and ensure that the calcium level is improved so as to prevent fractures and bone loss and has improvement effect on bone formation. Moreover, the invention adopts scientific and reasonable production process and better retains active constituents in various raw materials.

Description

technical field [0001] The invention relates to a composition, in particular to a composition for increasing bone density and a preparation method thereof. Background technique [0002] Osteoporosis is a bone metabolic disease that seriously endangers the health of the elderly, due to the decrease in the density of bone parenchyma structure. With the aging of the social population, the incidence of the disease is getting higher and higher, which is characterized by bone loss and susceptibility to fracture, which brings harm to society and family. The measurement of bone density is a necessary means to evaluate osteoporosis. There are many reasons for osteoporosis, one of which is the lack of calcium in food. Calcium is an important element in the human body. 99% of the calcium in the human body is stored in hard tissues, namely bones and teeth, and the remaining 1% is distributed in blood, muscles and other tissues. Calcium in bones is an important component of bone minera...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/39A61K33/10A61K31/7008
Inventor 张宏查圣华
Owner BEIJING TONGRENTANG HEALTH PHARMA
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