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Long-acting combination type wound dressing and preparation method thereof

A wound dressing and combined technology, which is applied in medical science, absorbent pads, bandages, etc., can solve the problems of long onset time, short duration, fast degradation, etc., and achieve the effect of short onset time and long action time

Inactive Publication Date: 2011-06-01
都本立
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention aims at the traditional single chitosan dressing with long onset time and insignificant effect, and single chitosan oligosaccharide with obvious effect, but rapid degradation, short time effect, frequent dressing changes, etc., and provides a long-acting combined dressing Wound dressing and method for its preparation

Method used

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  • Long-acting combination type wound dressing and preparation method thereof
  • Long-acting combination type wound dressing and preparation method thereof
  • Long-acting combination type wound dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: Accurately weigh 0.5 g of chitosan and place it in a stirrer, add 100 ml of purified water, add 0.4 ml of glacial acetic acid dropwise, and stir evenly at a stirring speed of 65 r / min until it is completely dissolved and becomes a homogeneous solution. Add 6 grams of gelatin to the solution, heat it on a 75°C water bath until the gelatin is completely dissolved, then add 1.5 grams of chitooligosaccharides and 10 grams of chitooligosaccharides and stir to dissolve them. The stirring speed is 150r / min. Then add 1 ml of glycerin and stir evenly until it is completely dissolved. The stirring speed is 100r / min and the pH is controlled to 6.5. Finally, filter and remove impurities, stand for defoaming, and sterilize separately, which is the finished product.

Embodiment 2

[0026] Example 2: Accurately weigh 2 grams of chitosan and place it in a stirrer, add 100 ml of purified water, add 1 ml of glacial acetic acid dropwise, and stir evenly at a stirring speed of 150 r / min until it is completely dissolved and becomes a uniform solution. Add 4 grams of gelatin to the solution, heat it on a water bath at 75°C until the gelatin is completely dissolved, and then add 4 grams of chitooligosaccharides and 6 grams of chitooligosaccharides and stir to dissolve them. The stirring speed is 150r / min. Then add 4 ml of glycerin and stir evenly until it is completely dissolved. The stirring speed is 100r / min, and the pH is controlled to 5.5. Finally, filter and remove impurities, stand for defoaming, and sterilize separately, which is the finished product.

Embodiment 3

[0027] Example 3: Accurately weigh 4 grams of chitosan into a stirrer, add 100 ml of purified water, add 3 ml of glacial acetic acid dropwise, and stir evenly at a stirring speed of 200 r / min until it is completely dissolved and becomes a uniform solution. Add 2 grams of gelatin to the solution, heat it on a water bath at 75°C until the gelatin is completely dissolved, then add 6 grams of chitooligosaccharides and 2 grams of chitooligosaccharides and stir to dissolve them at a stirring speed of 150r / min. Then add 6 ml of glycerin and stir evenly until it is completely dissolved. The stirring speed is 100r / min, and the pH is controlled to 5. Finally, filter and remove impurities, stand for defoaming, and sterilize separately, which is the finished product.

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Abstract

The invention relates to long-acting combination type wound dressing and a preparation method thereof. The long-acting combination type wound dressing comprises chitosan, oligo-chitosan, chitosan oligosaccharide, glacial acetic acid, isinglass, glycerol and purified water, wherein 100 milliliters of purified water contains 0.5g-8g of isinglass, 0.5g-10g of oligo-chitosan, 0.5g-10g of chitosan oligosaccharide, 0.3g-6g of isinglass, 0.3 milliliters-6 milliliters of glacial acetic acid and 1 milliliters-10 milliliters of glycerol. The long-acting combination type wound dressing is novel bio-hydrogel dressing which is short in onset time and is long in action time, can promote the healing of burn and scald wounds and acute and chronic wounds, and has three functions of hemostasis, analgesia and healing promotion; three main raw materials with different molecular weight gradients, such as chitosan, oligo-chitosan and chitosan oligosaccharide, are used, so as to achieve the purpose that the main raw materials are gradually absorbed in turn and exerts actions.

Description

Technical field [0001] The invention relates to a wound dressing and a preparation method thereof, in particular to a long-acting combined wound dressing and a preparation method thereof. Background technique [0002] Chitosan is a kind of biopolymer obtained by deacetylation reaction of chitin, one of the most abundant organic resources on the earth. Its chemical name is β-(1-4)-2-amino-2- Deoxy-D-glucan, currently mainly processed from the shells of shrimp and crabs in the ocean, is the only positively charged animal fiber that always exists in nature. In recent years, domestic and foreign countries have paid great attention to the development and utilization of chitin and its derivatives. , And found that it has a wide range of application prospects in the field of medicine. [0003] Chitooligosaccharides are a class of oligosaccharides produced by chemical degradation or enzymatic hydrolysis. The average molecular weight is generally between 2000 and 10000. It is biodegradable...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/28A61L15/20
Inventor 都本立孟祥锋杨毅
Owner 都本立
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