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Preparation method of traditional Chinese medicine emulsion

A technology of emulsion and traditional Chinese medicine, which is applied in the preparation of traditional Chinese medicine preparations and the field of preparation of traditional Chinese medicine emulsions. It can solve the problems of unsuitable preparations, floating and sinking of dispersed phase droplets, etc., so as to solve the problem of low oil utilization rate, improve utilization rate, and improve The effect of appearance

Active Publication Date: 2011-05-25
SHAN DONG DONG E E JIAO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are two treatment methods for the oil in the seed Chinese medicine. One is to extract the water-soluble components of the seed Chinese medicine with water, and most of the oil still exists in the seed medicine dregs. Small solvent extraction, but oil and water-soluble active ingredients cannot be miscible, and oil-water separation occurs, which does not meet the requirements of uniform preparation
In addition, the phenomenon of floating or sinking of the dispersed phase droplets is prone to occur during the emulsion placement process.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1 Preparation of Qingzao Jiufei Decoction Emulsion

[0025] (1) Press bitter almonds and black sesame seeds to filter the oil, filter the oil, heat it to remove water, and get the oil for later use; mix gypsum mulberry leaves, loquat leaves, ginseng, Ophiopogon japonicus, licorice and donkey-hide gelatin with 4 times the weight of water, Decoct for 3 times, filter the decoction, combine the filtrates, concentrate to a relative density of 1.31 (60°C) to obtain a water-soluble extract, and set aside;

[0026] (2), take by weighing the following components in the following parts by weight: fat: water: sucrose stearate (hydrophilic-hydrophobic balance value HLB=12)=10: 10: 1; the sucrose stearate emulsifier Dissolve in water, stir, heat in a water bath at 60°C, stir and dissolve evenly; add oil to a water bath at 60°C, pour into sucrose stearate aqueous solution, stir evenly, use a high-pressure homogenizer to emulsify once at normal pressure, pressurize Homogen...

Embodiment 2

[0031] (1) Press bitter almonds and black sesame seeds to filter the oil, filter the oil, heat it to remove water, and get the oil for later use; mix gypsum, mulberry leaves, loquat leaves, ginseng, Ophiopogon japonicus, licorice and donkey-hide gelatin with 5 times the weight of water , decocting twice, filtering the decoction, combining the filtrates, concentrating to a relative density of 1.31 (60°C), and obtaining a water-soluble extract, which is set aside;

[0032] (2), take by weighing the following components in the following parts by weight: fat: water: sucrose stearate (hydrophilic-hydrophobic balance HLB=10)=8: 12: 1.2; the sucrose stearate emulsifier Dissolve in water, stir, heat in a water bath at 50°C, stir and dissolve evenly; add oil to a water bath at 60°C, pour into sucrose stearate aqueous solution, stir evenly, use a high-pressure homogenizer to homogeneously emulsify once at normal pressure, pressurize Homogeneously emulsify at 25MPa for 3 times to obtain ...

Embodiment 3

[0037] (1) Press bitter almonds and black sesame seeds to filter the oil, filter the oil, heat it to remove water, and get the oil for later use; mix gypsum, mulberry leaves, loquat leaves, ginseng, Ophiopogon japonicus, licorice and donkey-hide gelatin and add 3 times the weight of water , decocted 3 times, filtered the decoction, combined the filtrates, concentrated to a relative density of 1.31 (60°C) to obtain a water-soluble extract, and set aside;

[0038] (2), take by weighing the following components in the following parts by weight: fat: water: sucrose stearate (hydrophilic-hydrophobic balance value HLB=14)=12: 8: 0.8; the sucrose stearate emulsifier Dissolve in water, stir, heat in a water bath at 70°C, stir and dissolve evenly; add oil to a water bath at 60°C, pour into sucrose stearate aqueous solution, stir evenly, and emulsify once at normal pressure with a high-pressure homogenizer, pressurize Homogeneously emulsify at 25MPa for 3 times to obtain an oil-in-water...

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PUM

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Abstract

The invention discloses a preparation method of a traditional Chinese medicine emulsion, which comprises the steps of: (1) extracting grease ingredients and water-soluble ingredients in raw material drugs to obtain grease and water-soluble extract; (2) dissolving sucrose stearate which is used an emulsifying agent in water, stirring, heating by water bath, stirring to dissolve uniformly to obtain sucrose stearate aqueous solution; subjecting the grease to water-bath heating and then pouring the grease to the sucrose stearate aqueous solution, uniformly stirring, emulsifying at normal pressure at first, and then emulsifying by increasing the pressure to obtain oil-in-water emulsion; (3) uniformly mixing the oil-in-water emulsion with syrup having the same weight; and (4) mixing the water-soluble extract with the oil-in-water emulsion syrup to obtain the traditional Chinese medicine emulsion. The method of the invention enhances the utilization rate of grease ingredients in the traditional Chinese medicines, improves the appearance of emulsified preparation and settles the problems of low utilization rate of grease, easy separation between oil and water, instability and the like during traditional Chinese medicine emulsion preparation.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine preparation, in particular to a preparation method of a traditional Chinese medicine emulsion, and belongs to the field of traditional Chinese medicine preparations. Background technique [0002] The active ingredients of traditional Chinese medicine can be divided into water-soluble ingredients and fat-soluble ingredients. Oil is an active ingredient of fat-oily ingredients. Oil is mainly found in seed-based traditional Chinese medicines, such as almonds, black sesame, peach kernels, etc., which have the functions of moisturizing the intestines, moistening the lungs, and nourishing . [0003] At present, there are two treatment methods for the oil in the seed Chinese medicine. One is to extract the water-soluble components of the seed Chinese medicine with water, and most of the oil still exists in the seed medicine dregs. Small solvent extraction, but the oil and water-s...

Claims

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Application Information

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IPC IPC(8): A61K36/00A61K9/107A61K36/8968A61P11/00A61K33/06A61K35/36
Inventor 尤金花田守生秦玉峰张守平张淹
Owner SHAN DONG DONG E E JIAO
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