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Externally applied compound composition consisting of tadines and leukotriene antagonist

A leukotriene antagonist and composition technology, which are applied in the directions of medical preparations containing active ingredients, pharmaceutical combinations, active ingredients of heterocyclic compounds, etc.

Inactive Publication Date: 2011-05-25
李仲昆
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Loratadine and its salts and montelukast and its salts of the external compound composition has not been reported

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Loratadine hydrochloride 1g; Montelukast sodium 1g; Vaseline 998g. Make ointment according to the ointment preparation method.

Embodiment 2

[0013] Loratadine Hydrochloride 1g; Montelukast Sodium 1g; Sodium Chloride 9g, EDTA Disodium 0.1, Ethylparaben 0.3, add distilled water to 1000, dissolve, mix, sterilize, aliquot Get nose drops.

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PUM

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Abstract

The invention relates to an externally applied compound composition consisting of tadines and a leukotriene antagonist, wherein the tadines are preferably loratadine and salt thereof; and the leukotriene antagonist is preferably montelukast and salt thereof. The externally applied compound composition can be prepared into externally applied preparations such as nasal drops, eye drops, eye ointments, ointments, gel, inhalants, patches and the like. The externally applied compound composition can be used for local treatment for allergic diseases, can quickly improve allergic symptoms, and has the characteristics of high efficiency, safety, convenient use and the like.

Description

Technical field: [0001] The invention relates to an external compound composition composed of stadines and leukotriene antagonists, the external compound composition can be used for treating allergic diseases, and the external compound composition can be made into nasal drops and eye drops , eye ointment, ointment, gel, inhalant, patch and other external preparations. Background technique: [0002] The incidence of allergic diseases is high. Oral anti-allergic preparations need to be absorbed through the gastrointestinal tract, and then redistributed in the skin and mucous membranes through blood circulation to take effect. The onset of action is slow, the drug concentration in the affected part is low, and the systemic distribution of the drug may also cause various adverse effects. reaction. Although injection of anti-allergic preparations takes effect quickly, the drug also has the disadvantages of systemic distribution, low drug concentration in the affected area, and h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/47A61K31/4545A61P37/08
Inventor 李仲昆
Owner 李仲昆
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