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Preparation method of medicament-loaded biodegradable nano-fiber medical dressing

A nanofiber, biodegradable technology, applied in dressings, viscous dressings, medical science, etc., can solve problems such as iatrogenic pollution, damage to new tissue, wound adhesion, etc., to achieve accelerated healing, good absorption, and conducive to growth and regeneration Effect

Active Publication Date: 2011-05-25
ROOSIN MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are many inconveniences in the use of medical dressings. Some dressings use non-degradable polyacrylonitrile materials as scaffold materials, causing iatrogenic pollution; When the new tissue is damaged, it brings great pain to the patient

Method used

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  • Preparation method of medicament-loaded biodegradable nano-fiber medical dressing
  • Preparation method of medicament-loaded biodegradable nano-fiber medical dressing
  • Preparation method of medicament-loaded biodegradable nano-fiber medical dressing

Examples

Experimental program
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Effect test

Embodiment 1

[0032] (1) The mixture of CS powder and PEO (its weight ratio is CS / PEO=3 / 7) is dissolved in the acetic acid solution of 95wt%, is made into the solution that the percentage by weight is 3wt%, then fully stirs the solution, so that completely After dissolving, the solution was placed in ultrasonic for 1 hour so that all the bubbles were separated out to obtain a transparent CS electrospinning solution.

[0033](2) Add the CS electrospinning solution prepared in step (1) into the syringe pump, adjust the voltage to 20kV; the distance from the spinneret to the collecting plate is 12cm; the flow rate of the spinneret spinning solution is 0.5mL / h. The device was activated for electrospinning, and CS nanofibers (such as figure 1 ).

[0034] (3) Cross-link the CS nanofibers obtained in step (2) with glutaraldehyde for 2 hours, soak the cross-linked chitosan nanofibers in the solvent of the pore-forming agent, and selectively remove the pore-forming agent and excess cross-linking a...

Embodiment 2

[0037] (1) HA powder of Mw=1,000,000 and PVP (its weight ratio is HA / PVP=5 / 5) are dissolved in deionized water, formic acid and N, in the mixed solvent that N-dimethylformamide forms (deionized Water / formic acid / N, N-dimethylformamide=25 / 50 / 25), be made into the solution of 1wt% by weight percent, then the solution is fully stirred, so that dissolve completely, the solution is placed in ultrasonic for 2 hours to make All the bubbles are separated out to obtain a transparent HA solution.

[0038] (2) Add the HA electrospinning solution prepared in step (1) to the syringe pump, adjust the voltage to 15kV; the distance from the spinneret to the collecting plate is 15cm; the flow rate of the spinneret spinning solution is 0.5mL / h; The spinning ambient temperature was 18°C. The device was activated for electrospinning of hyaluronic acid, and HA nanofibers (such as Figure 4 ).

[0039] (3) Cross-linking the hyaluronic acid nanofibers obtained in step (2) with divinyl sulfone for...

Embodiment 3

[0042] (1) The mixture of CS powder and PEG (its weight ratio is CS / PEG=9 / 1) is dissolved in the acetic acid solution of 10wt%, is made into the solution that weight percent is 8wt%, then fully stirs solution, so that completely Dissolved, the solution was placed in ultrasonic for 2 hours to make all the bubbles precipitate out to obtain a transparent CS electrospinning solution.

[0043] (2) Add the CS electrospinning solution prepared in step (1) into the syringe pump, adjust the voltage to 25kV; the distance from the spinneret to the collecting plate is 20cm; the flow rate of the spinneret spinning solution is 1mL / h. The device was activated for electrospinning, and CS nanofibers were obtained on the collecting plate.

[0044] (3) The CS nanofibers obtained in step (2) were crosslinked with genipin for 2 hours, and the crosslinked chitosan nanofibers were soaked in the solvent of the pore-forming agent to selectively remove the pore-forming agent and excess crosslinking ag...

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Abstract

The invention relates to a method for preparing a medicament-loaded biodegradable nano-fiber medical dressing. The method comprises the following steps: dissolving hyaluronic acid in a mixed solvent comprising water, methanoic acid and N,N-dimethylformamide (DMF) for preparing solution, standing the solution under ultrasonic waves for 1 hour for completely releasing bubbles and further obtaining transparent hyaluronic acid solution; adding the prepared hyaluronic acid electrospinning solution into an injection pump, adjusting the appropriate spinning voltage, the distance from a spinneret to a collecting plate and the flow rate of the spinning solution of the spinneret, electrospinning onto a folding fan-shaped aluminum foil within the temperature range of 5-60 DEG C, and getting hyaluronic acid nano-fiber non-woven fabric with the fiber average diameter of 200-600nm. The preparation process and the post-treatment process step are simple, the hyaluronic acid nano-fiber non-woven fabric can be obtained within the larger temperature range, and the diameter distribution of the obtained hyaluronic acid nano-fiber is uniform.

Description

technical field [0001] The invention relates to a method for preparing a drug-loaded biodegradable nanofiber medical dressing. Background technique [0002] Electrospinning is a processing method in which charged polymer solutions or melts are jetted in an electrostatic field to prepare polymer ultrafine fibers. When the applied electric field reaches a certain critical value, the fibers will be ejected from the spinneret At the same time, the solvent gradually evaporates away from the charged fibers, and the dried fibers fall on the collecting plate to form ultra-fine nanofiber non-woven fabrics. The prepared nanofiber non-woven fabric has the advantages of large specific surface area, high porosity, fineness and uniformity of fibers, and large aspect ratio. Generally, the smaller the material system for carrying drugs, the easier it is for the drugs to be absorbed by the body. Therefore, nanofibers have great application possibilities in the sustained release of drugs. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F13/02A61L15/44A61L15/28
Inventor 马贵平聂俊刘洋柳建伟
Owner ROOSIN MEDICAL CO LTD
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