Polyamine enhanced formulations for triptan compound iontophoresis

Abstract

A patch and compositions for iontophoresis of triptan compounds are described.

Description

Technical field [0001] This application claims the priority of US application serial number 12 / 214,555 filed on June 19, 2008, the entire content of which is hereby incorporated by reference. Background technique [0002] The method of iontophoresis (iontophoresis) was described by LeDuc in 1908, so it has found commercial use in the delivery of ionically charged therapeutic agent molecules such as pilocarpine, lidocaine and dexamethasone. In this delivery method, positively charged ions are driven through the skin at the anode position of the electrolysis system, while negatively charged ions are driven through the skin at the cathode position of the electrolysis system. [0003] In the early days, and now, iontophoresis devices typically consisted of two electrodes affixed to the patient by an adhesive material, each connected to a remote power source by a wire, usually an electrical instrument controlled by a microprocessor. [0004] Recent publications indicate that sumatriptan ...

AI Technical Summary

Problems solved by technology

A notable limitation of the device is the two-component construction of the delivery system; the wire connection between the controller and the patch is cumbersome to the wearer

Furthermore, programmable controllers can be expensive if exploited on a single-use basis, or, if exploited on a repeated-use basis, programmable controllers can be lost, contaminated, damaged, etc.

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