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General flavone extractive of immature bitter orange or bitter orange extracted through water decoction and use of general flavone extractive

A technology of total flavonoids and extracts, which is applied to medical preparations containing active ingredients, drug combinations, plant raw materials, etc., can solve the problems that the similarities of actions are not fully exploited, the resources are not widely used, etc., and can promote gastric motility. Effect

Active Publication Date: 2011-05-11
JIANGZI QINGFENG PHARMACEUTICALS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Citrus aurantium and Fructus aurantium are only used in a small amount in clinical formulas and Chinese patent medicine preparations, and a large amount of resources have not been widely used. Their natural effects of breaking Qi and eliminating stagnation may not be fully exploited in the similarity with modern gastric motility-promoting drugs.

Method used

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  • General flavone extractive of immature bitter orange or bitter orange extracted through water decoction and use of general flavone extractive
  • General flavone extractive of immature bitter orange or bitter orange extracted through water decoction and use of general flavone extractive
  • General flavone extractive of immature bitter orange or bitter orange extracted through water decoction and use of general flavone extractive

Examples

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Effect test

Embodiment 1

[0035] Preparation method: take citrus aurantium or citrus aurantium, cut into decoction pieces, add 7 times the amount of water, decoct 3 times, decoct and extract for 1 hour each time, combine the decoction liquid, filter, and the filtrate passes through the D101 macropores that have been processed Resin, eluted with water and 18% ethanol in turn to remove impurities, then eluted with 35% ethanol and 0.5% sodium hydroxide, collected 35% ethanol eluate, concentrated under reduced pressure to a flow immersion solution with a relative density of about 1.25 (55°C) The paste is dried under reduced pressure (60°C), crushed, and obtained.

Embodiment 2

[0037] Preparation method: take citrus aurantium or citrus aurantium, crush them, pass through an 8-mesh sieve, add water to decoct 3 times, add 8 times the amount to boil for 2.5 hours for the first time, add 6 and 5 times the amount to decoct for 1 hour for the second and third times respectively , filtered, combined the filtrate, the filtrate passed through the AB-8 macroporous resin column that had been treated, and eluted with water, 15% ethanol, 45% ethanol, 1% sodium hydroxide successively, collected the 45% ethanol eluate, and depressurized Concentrate to a fluid extract with a relative density of about 1.31 (65°C), dry under reduced pressure (70°C), and pulverize to obtain.

Embodiment 3

[0039] Preparation method: take citrus aurantium or citrus aurantium, cut into decoction pieces, add 8 times the amount of water, decoct 3 times, extract for 1.5 hours each time, combine the decoction liquid, filter, and the filtrate passes through the D101 macropore that has been processed Resin, eluted with water and 16% ethanol to remove impurities in turn, then eluted with 40% ethanol and 0.6% sodium hydroxide, collected the 40% ethanol eluate, concentrated under reduced pressure to a flow immersion solution with a relative density of about 1.20 (50°C) The paste was dried under reduced pressure (65°C), crushed, and obtained.

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Abstract

The invention relates to a general flavone extractive of an immature bitter orange or a bitter orange. The general flavone extractive is extracted through the following steps: cutting the immature bitter orange or the bitter orange into decoction pieces or smashing the immature bitter orange or the bitter orange, adding 4 to 15 times of water, decocting 1 to 3 times (1 to 3 hours each time), merging the decoction liquids, filtering through processed non-polar big hole resin, eluting by water and alcohol of which the concentration is lower than 20 percent sequentially to remove impurities, eluting by alcohol of which the concentration ranges from 25 to 90 percent and sodium hydrate of which the concentration ranges from 0.5 to 2 percent, collecting alcohol eluant, depressuring and concentrating to obtain a liquid extract of which the relative density is 1.20 to 1.40 (under the temperature ranging from 50 DEG C to 70 DEG C), depressuring and drying under the temperature ranging from 60 DEG C to 80 DEG C, and smashing to obtain the general flavone extractive of the immature bitter orange or the bitter orange. The extractive can be used for preparing medicines used for curing gastrointestinal dyskinesia-type functional indigestion, epigastralgia, abdominal distention, asitia, eructation, nausea, and vomit caused by chemotherapeutics and other reasons, and is prepared into dosage forms acceptable for pharmacology.

Description

technical field [0001] The invention relates to a decocted and extracted total flavonoid extract of Fructus Aurantii or Fructus Fructus Fructus and its application. Background technique [0002] Functional dyspepsia (FD) is a common and frequently-occurring disease. Also known as gastric insufficiency, or gastric motility disorder. Is a common clinical syndrome, foreign statistics show that 1 / 3 of the population suffered from FD, accounting for 20% to 30% of outpatients. Domestically, it accounts for about 50% of digestive system outpatients, and occurs in 20% to 40% of normal people. In addition, more than 80% of cancer patients will cause vomiting after chemotherapy. The main anti-vomiting drugs are Metoclon and Zofran, but chemical drugs are accompanied by fatigue, dizziness, headache, and even neck and back muscle pain. Cramp symptoms. [0003] At present, Western medicine mainly treats modinline, cisapride, mosapride, etc.; however, with the extensive use of them,...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61P1/08A61P1/14
Inventor 吕武清唐春山谢宁杨小玲孙继寅宋友昕李志勇
Owner JIANGZI QINGFENG PHARMACEUTICALS INC
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