Novel method of early cancer diagnosis based on gold nanorod

A technology of gold nanorods and early diagnosis, which is applied in the field of nanobiomedicine and can solve problems such as large limitations and long time consumption

Inactive Publication Date: 2011-02-16
CHANGCHUN UNIV OF SCI & TECH
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Problems solved by technology

[0002] At present, the standard method of clinical diagnosis of cancer is to use the means of medical pathological detection: the fresh tissue of the surgically resected lesion is made into sections, stained and observed under a microscope, but this method has great limitations: this diagnostic method consumes It takes a long time, and the test results are somewhat subjective: for the same basal cell carcinoma case, the concordance rate between the conclusions drawn by a single pathologist and the test results drawn by other experts is only 65%

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  • Novel method of early cancer diagnosis based on gold nanorod
  • Novel method of early cancer diagnosis based on gold nanorod
  • Novel method of early cancer diagnosis based on gold nanorod

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Embodiment Construction

[0016] Below in conjunction with embodiment further set forth the specific embodiment of the invention.

[0017] 1. Select 3.3'-diethylthiatricarbocyanine iodide (3.3'-diethylthiatricarbocyanine iodide chemical formula C 25 h 25 IN 2 S 2 DTTC for short) is used as the SERS active probe molecule to configure the gold nanorod solution;

[0018] 2. Inject the gold nanorod solution (the ratio of solution to body weight is 1:1000) intravenously into the human body;

[0019] 3. After 48-72 hours, the gold nanorods have been enriched in the cancer cell tissue at the lesion site;

[0020] 4. Use the Raman spectrometer to detect the suspected lesion of the patient, and repeat the detection for the area with obvious detection signal;

[0021] 5. Compare the obtained Raman spectrum with the Raman spectrum data of the Raman probe molecule DTTC to diagnose the patient's condition.

[0022] 6. Excretion period: 72 hours after injection, most of the gold nanorods in normal tissues will...

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Abstract

The invention belongs to the field of nano-biomedicine. The traditional early cancer diagnosis has the defects of low sensitivity, high cost, inconvenient use, and the like. The surface enhanced Raman scattering technology of gold nanorods can realize the sensitivity of single molecule detection. In the invention, by using the strong absorption characteristic of cancer cells for the gold nanorods, the gold nanorods are collected in a tumor tissue through intravenous injection, Raman probe molecules are attached to the surfaces of the gold nanorods, and the early-period and high-sensitivity detection of cancers is realized by measuring a Raman spectrum of the Raman probe molecules. Absorption peaks of the selected gold nanorods are in a near-infrared wave band, thereby pump light and scattered light can be easy to enter and perforate a human body. The invention provides a novel, efficient and convenient method for the clinical diagnosis of early cancers.

Description

Technical field [0001] This patent belongs to the field of nano biomedicine. It is used for the early diagnosis of tumors and cancers. It can diagnose epithelial tissue tumors and tumors in some organs. The application range includes: skin cancer, oral cancer, esophageal cancer, gastric cancer, intestinal cancer, breast cancer, cervical cancer, etc. Background technique [0002] At present, the standard method of clinical diagnosis of cancer is to use the means of medical pathological detection: the fresh tissue of the surgically resected lesion is made into sections, stained and observed under a microscope, but this method has great limitations: this diagnostic method consumes It takes a long time, and the test results are somewhat subjective: for the same basal cell carcinoma case, the concordance rate between the conclusions drawn by a single pathologist and the test results drawn by other experts is only 65%. Therefore, there is a need for a new detection method that ca...

Claims

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Application Information

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IPC IPC(8): A61K49/00
Inventor 蔡红星高健赫谭勇张天幕刘丽伟杨家伟赵丽辉张喜和
Owner CHANGCHUN UNIV OF SCI & TECH
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