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Composition for preventing or treating brain diseases

A composition and disease technology, applied in the directions of drug combinations, nervous system diseases, medical preparations containing active ingredients, etc., can solve the problems of great necessity, and achieve the effect of promoting the generation and inhibiting the apoptosis of neuronal cells

Inactive Publication Date: 2011-02-09
REGERON
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, there are many tendencies to avoid visiting organs for the treatment of stress-induced depression, serotonin nervous system disorders and brain damage induced by stress, etc., and thus, actually have the function of treating stress depression The necessity of functional food is very large

Method used

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  • Composition for preventing or treating brain diseases
  • Composition for preventing or treating brain diseases
  • Composition for preventing or treating brain diseases

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Experimental program
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Embodiment

[0071] Materials and methods

[0072] 1. Preparation of Stannioealcin 2: STC2

[0073] Genomic DNA is obtained from HEF (human embryo fibroblast). This was cut with BamHI (Takara, Japan) and used as a template, and PCR was performed to obtain DNA fragments encoding stanniocalcin 2 with four exons. In order to connect each exon DAN fragment, primers are designed so that the 19 bases of a part of the connection site can form base pairing with each other. PrimeSTAR is used in all PCRs TM HS DNA polymerase (Takara, Japan). The first PCR method to amplify exons 1, 2, 3, and 4 of stanniocalcin 2 is as follows. Using the genomic DNA cut with BamHI (Takara, Japan) as a template, PCR was performed using hSTC21U primer (Bioneer, Korea) and hSTC22D primer pair (30 cycles; 98°C for 10 seconds, 55°C for 5 seconds, 72°C) After 30 seconds), the 169bp exon 1 was amplified. Using the same method, the hSTC23U and hSTC24D primer pairs were used to obtain 163 bp exon 2, the hSTC25U and hSTC26D ...

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Abstract

The present invention relates to a composition for preventing or treating neuropsychiatry disorders, particularly brain diseases, and improving cognitive function by inhibiting neuronal cell killing and / or accelerating neuronal cell production. The composition contains a stanniocalcin 2 as an active ingredient for preventing or treating neurological diseases, more particularly brain diseases and improving cognitive function.

Description

Technical field [0001] The present invention relates to a composition for the prevention or treatment of brain diseases and a composition for improving cognitive function, and more specifically to a composition for neurological diseases containing stanniocalcin 2 as an active ingredient, and particularly to a composition for prevention or treatment of brain diseases and A composition for improving cognitive function. Background technique [0002] Looking at the proportion of the elderly population in South Korea published by the National Statistics Agency in July 2007, it was found that in 2000, South Korea’s population over the age of 65 accounted for 7.3% of the total population. It has been immersed in an aging society. In 2007, it was 9.3%, compared with 5 years. The previous increase was 2.0%. If this trend is followed, it is expected that Korea’s aging index (compared to the proportion of people over 65 years old per 100 people aged 0-14) will be 429 in 2050, which will be...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/22
CPCA23V2002/00A61K38/22A61P25/00A61P25/14A61P25/16A61P25/18A61P25/24A61P25/28A61P43/00A23V2200/322A61K35/12A61K35/60
Inventor 李熙济卞钟善李均永白常贞吴达均
Owner REGERON
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