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Amino acid Schiff base ligand-containing vanadium oxide compound

An amino acid and Schiff base technology, applied in the fields of compounds, organic chemistry, and drug combinations of Group 5/15 elements of the periodic table, can solve problems such as toxicity and difficult absorption, and achieve reduced toxicity, strong coordination ability, The effect of saving raw materials

Inactive Publication Date: 2011-02-09
LIAONING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But since VO 2+ Toxic and poorly absorbed, scientists have focused on prolonging the drug's action time and reducing its toxicity

Method used

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  • Amino acid Schiff base ligand-containing vanadium oxide compound
  • Amino acid Schiff base ligand-containing vanadium oxide compound
  • Amino acid Schiff base ligand-containing vanadium oxide compound

Examples

Experimental program
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Effect test

Embodiment 1

[0018] Embodiment 1, with 0.5mmol VOSO 4 ·nH 2 O (0.3mmol, 0.08g, based on 71% VOSO 4 ) and 0.5mmol aminopropionic acid (0.04g, 0.5mmol) were dissolved in a mixed solvent of 11mL methanol and 1mL water, stirred at room temperature for 30min, then added dropwise salicylaldehyde (0.06g, 0.5mmol), and continued to stir for 3h to obtain red The brown solution was filtered, and the obtained reddish-brown filtrate was placed at room temperature, and dark red crystals precipitated after 3 days. Weighing 0.13g, productive rate: 83% (with VOSO 4 The vanadium in the base is the benchmark). Elemental analysis (C 20 h 19 N 3 o 5 V)

[0019] Measured value: 55.51% for C, 4.47% for H, 9.69% for N, theoretical value: 55.56% for C, 4.43% for H, 9.72% for N.

Embodiment 2

[0020] Embodiment 2, with 0.5mmol VOSO 4 ·nH 2 O (0.3mmol, 0.08g, based on 71% VOSO 4 ) and 0.5mmol of aminopropionic acid (0.04g, 0.5mmol) were dissolved in a mixed solvent of 11mL of ethanol and 1mL of water, then added dropwise salicylaldehyde (0.06g, 0.5mmol), stirred at room temperature for 3h to obtain a reddish-brown turbid liquid, filtered , The obtained reddish-brown filtrate was placed at room temperature, and dark red crystals were precipitated after 7 days. Weighing 0.12g, productive rate: 79% (with VOSO 4 The vanadium in the base is the benchmark). Elemental analysis (C 20 h 19 N 3 o 5 V) Measured value: C is 55.51%, H is 4.47%, N is 9.69%, theoretical value: C is 55.56%, H is 4.43%, N is 9.72%.

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Abstract

The invention provides an amino acid Schiff base ligand-containing vanadium oxide compound and a preparation method thereof. The toxicity of VO2+ can be reduced by selecting a proper substituent, taking amino acid Schiff base as a ligand, and chemically combining with vanadium to form a tetravalent or pentavalent organic vanadium compound. The vanadium oxide compound has high coordination capability, and can control and stabilize a vanadium oxide coordination compound to fulfill the aim of directionally designing, and regulating molecular configuration and characteristic.

Description

technical field [0001] The invention belongs to the field of inorganic chemistry, and in particular relates to the preparation and structural characterization of a novel vanadyl amino acid Schiff base compound. technical background [0002] At present, people pay more and more attention to the design and synthesis of coordination polymer molecules, especially the development and research of heterocyclic drugs. Among them, the research on vanadyl amino acid Schiff base compounds has attracted much attention. Because, although the content of vanadium in plants and animals is very small, its compounds have very interesting biological and pharmaceutical activities, especially insulin-like activities. Vanadium can promote blood sugar transportation and metabolism, biolipid, DNA and protein synthesis, and also promote cell division. In addition, vanadate also has the functions of stimulating blood sugar absorption, glycolysis and anti-tumor. In a word, the study of the relation...

Claims

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Application Information

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IPC IPC(8): C07F9/00A61P3/10
Inventor 赵海燕邢永恒
Owner LIAONING NORMAL UNIVERSITY
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