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Application of juglans mandshurica maxim. ethyl acetate part in preparing alpha-glucosidase inhibitor medicament

A technology of catalpa ethyl acetate and glucosidase, applied in the field of medicine

Inactive Publication Date: 2011-01-12
吉林天药药物研发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Before the completion of the present invention, there was no report on the application of the ethyl acetate part of Juglans as an α-glucosidase inhibitor in the prevention and treatment of hypoglycemia

Method used

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  • Application of juglans mandshurica maxim. ethyl acetate part in preparing alpha-glucosidase inhibitor medicament
  • Application of juglans mandshurica maxim. ethyl acetate part in preparing alpha-glucosidase inhibitor medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 , Preparation of Ethyl Acetate Part of Peel of Walnut

[0028] Take 1kg of dried walnut tree peel, crush it, extract 3 times with 70% ethanol solution for 2 hours each time, combine the extracts, concentrate, add water to 1ml medicinal solution containing 1g medicinal materials, extract 5 times with ethyl acetate, 250ml each time , Combine the ethyl acetate extracts, concentrate and dry to obtain ethyl acetate fraction. The yield was 1.85%.

Embodiment 2

[0029] Example 2 And preparation of ethyl acetate part of walnut bark

[0030] Take 1kg of dried walnut tree bark, crush it, extract 3 times with 80% ethanol solution for 3 hours each time, combine the extracts, concentrate, add water to 1ml medicinal solution containing 1g medicinal materials, and extract 5 times with ethyl acetate each time 250ml, combine the ethyl acetate extracts, concentrate and dry to obtain ethyl acetate fraction. The yield was 1.72%.

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PUM

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Abstract

The invention discloses application of juglans mandshurica maxim. peel or bark ethyl acetate part in preparing a blood sugar reducing medicament, in particular new application of the juglans mandshurica maxim. peel or bark ethyl acetate part in preparing an alpha-glucosidase inhibitor medicament. The alpha-glucosidase inhibitor medicament can be prepared from the juglans mandshurica maxim. ethyl acetate part or a composition containing the juglans mandshurica maxim. ethyl acetate part.

Description

Technical field [0001] The invention relates to a method for extracting the ethyl acetate part of Juglans mandshurica, a traditional Chinese medicine, which is proved to have new medical uses through pharmacological experiments. Specifically, the ethyl acetate part of the root bark or peel of Juglans mandshurica is used as an α-glucosidase inhibitor in the preparation of hypoglycemic drugs. It belongs to the field of medical technology. Background technique [0002] Diabetes is a group of clinical syndromes caused by the interaction of genetic and environmental factors. It is caused by absolute or relative insufficient insulin secretion and decreased sensitivity of target tissues to insulin, causing a series of metabolisms such as sugar, fat, protein, water and electrolytes in the body. Disorders, with high blood sugar as the main common sign. Chronic illness can cause damage to multiple systems, and acute metabolic disorders such as ketoacidosis can occur in severe conditions ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/52A61P3/10A61K131/00A61K125/00
Inventor 赵全成马吉胜李庆杰赵文杰南敏伦王莲萍赫玉芳
Owner 吉林天药药物研发有限公司
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