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Stellera chamaejasme L extract and anti-tumor action thereof

A technology of chamaejasma chamaejasme and extracts, which can be used in antineoplastic drugs, drug combinations, plant raw materials, etc., and can solve problems such as expensive, temporary but not permanent, and inaccurate curative effects

Active Publication Date: 2010-12-29
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Some of the extracts in the existing literature are palliative but not the root cause, some use expensive ingredients, and some have been discontinued during the development process due to uncertain curative effects

Method used

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  • Stellera chamaejasme L extract and anti-tumor action thereof
  • Stellera chamaejasme L extract and anti-tumor action thereof
  • Stellera chamaejasme L extract and anti-tumor action thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0173] Add 500 g of chamaejasma to 2 L of absolute ethanol, reflux extraction 3 times, 2 hours each time, combine the extracts, recover ethanol under reduced pressure, dry in a water bath, and then dry under reduced pressure (70°C) to obtain extract 2.

[0174] Add 2000g of chamaejasma medicinal material, add 7L of absolute ethanol, reflux extraction 3 times, 2h each time, combine the extracts, concentrate under reduced pressure to 1 / 5 volume, add an equal volume of water, volatilize until there is no alcohol smell, and apply macroporous resin HPD100 (3.3kg), eluted with water, 40% ethanol, and 80% ethanol in 2.5 column volumes each, dried in a water bath, and dried under reduced pressure (70°C) to obtain extracts 3, 4, and 5, respectively.

[0175] Extract 2 (10.0g) was put on polyamide column (column volume 900ml, about 280g, polyamide pretreatment), washed with water, 30% ethanol, 60% ethanol, 100% ethanol respectively for 3 column volumes, and recovered ethanol under reduce...

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PUM

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Abstract

The invention relates to a Stellera chamaejasme L extract and an anti-tumor action thereof. The Stellera chamaejasme L extract of the invention is extracted by absolute ethyl alcohol to obtain a primary extract; the primary extract is further treated by macroporous resin column chromatography or polyamide column chromatography and then eluted by water and ethyl alcohol to obtain a secondary extract; and in the secondary extract, the secondary extract separated by a macroporous resin column is further treated by polyamide column chromatography and then eluted by water and ethyl alcohol to obtain a tertiary extract.

Description

Technical field: [0001] The invention relates to a new extract of the traditional Chinese medicine Daphne chamaejasme and its extraction method and application. Background technique: [0002] Stellera chamaejasme (Stellera chamaejasme L.) is the root of Stellera chamaejasme. It is the authentic product of Stellera chamaejasme. It was first recorded in "Shen Nong's Materia Medica". The Liver and Spleen Meridians have the function of "dispelling water, eliminating phlegm and resolving stagnation", and are mainly used to treat "accumulation of diet, cold and hot air". Qing Dynasty Zhang Zhicong's "Materia Medica Chongyuan" notes: "Break the accumulation, the diet will stagnate and become a cold and heat disease, which can also be cured." Sun Simiao's note: "Accumulated, the airway is not good, so the ears. Those who eat cold and hot, lose the qi. Its cure is qi stagnation and water accumulation, and this medicine can be prescribed." Li Shizhen listed it as inferior in "Compend...

Claims

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Application Information

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IPC IPC(8): A61K36/47A61P35/00A61K125/00
Inventor 朱晓新潘国凤刘安李玉洁杨庆翁小刚
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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