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Application of oryzanol

A technology with uses and obstacles, applied in the field of medicine, can solve problems such as no relevant reports

Active Publication Date: 2012-04-18
BEIJING CENTURY BIOCOM PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although oryzanol and its purified products have a certain effect on the treatment of insomnia, there is no relevant report in the prior art on the effect of maintenance disorder insomnia, which is more serious and difficult to treat insomnia, especially chronic maintenance disorder insomnia.

Method used

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  • Application of oryzanol
  • Application of oryzanol
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1 Cycloarpinenol Ferulate Tablets

[0021] Take 2g of cycloartenol ferulate, 10g of lactose, 8g of microcrystalline cellulose, 10g of PVPP, 10g of PVP K30 and 2g of micropowdered silica gel, mix them evenly and press into tablets to obtain cycloartenol ferulate tablets 200 tablets.

Embodiment 2

[0022] Example 2 Cycloarpinenol Ferulate Capsules

[0023] Take 500ml of 95% ethanol, 250g of povidone K15, fully oscillate and dissolve, add 30g of cycloartenyl ferulic acid ester, heat and stir at 80°C for about 10 minutes, and when the obtained solution is concentrated to about 80ml, take it out and dry it in an oven. The obtained solid is pulverized and passed through an 80-mesh sieve, uniformly mixed with starch, then an appropriate amount of 5% starch slurry is added to granulate, dried, magnesium stearate is added to mix evenly, and capsules are obtained to obtain 1000 capsules.

Embodiment 3

[0024] Embodiment 3 cycloartenol ferulic acid ester emulsion

[0025] Take 15g of camellia oil for injection, 0.5g of cycloartenol ferulic acid ester, stir in an oil bath at 120°C until completely dissolved, cool down to 80°C, add 1.8g of soybean oil, 0.2g of oleic acid, and stir until a uniform oil phase is formed; Take 80ml of water for injection, add 2.25g of Tween 80 and 1g of polyoxyethylene hydrogenated castor oil, stir and dissolve evenly to form an aqueous phase. Mix and stir the oil phase and water phase for half an hour to form colostrum, add water for injection to 100ml, stir evenly, use a high-pressure homogenizer to homogenize to an emulsion with a consistent particle size, decarbonize, sterilize and filter, and then fill it into a vial. 50 bottles.

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Abstract

The invention discloses oryzanol, oryzanol extracts, cycloartenyl ferulate and 24-methylene cycloartenyl ferulate, relating to application of cycloartenyl ferulate in preparing medicaments for treating maintaining disorder type insomnia, particularly chronic maintaining disorder type insomnia. The experiments performed by the applicant show that the oryzanol, the oryzanol extracts, the cycloartenyl ferulate and the 24-methylene cycloartenyl ferulate all have certain treatment effects on treating the maintaining disorder type insomnia, wherein the cycloartenyl ferulate has an excellent effect on treating the maintaining disorder type insomnia, particularly the chronic maintaining disorder type insomnia.

Description

technical field [0001] The invention discloses oryzanol, oryzanol purified product, cycloartenyl ferulic acid ester and 24-methylene cycloartenyl ferulic acid ester, especially cycloartenyl ferulic acid ester for preparing treatment maintenance The use of the disorder-type insomnia medicine, especially the use for preparing the medicine for treating chronic maintenance disorder-type insomnia, belongs to the field of medicine. Background technique [0002] Insomnia is a pathological state with unsatisfactory sleep quality for a long time. It is usually manifested as difficulty in falling asleep, inability to fall asleep, persistent sleep difficulty, premature or intermittent awakening leading to insufficient sleep. Drugs are a common solution for insomnia treatment. For modern people, insomnia is one of the most common sleep disorders. Long-term insomnia will have harmful effects on the circulation of carbohydrates and endocrine functions in the human body, and impair the bod...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/575A61P25/20
Inventor 郝守祝
Owner BEIJING CENTURY BIOCOM PHARMA TECH
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