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Avenanthramide-containing compositions

A technology of oat anthramid and composition, which is applied in the direction of drug combinations, medical preparations containing active ingredients, plant raw materials, etc., and can solve the problems of not providing anti-irritation properties

Inactive Publication Date: 2010-10-06
CEAPRO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No data provided on anti-irritation and redness reduction

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 12

[0100] Example 12 demonstrates beta(1) prepared according to the methods described in U.S. Patent Application Nos. 10 / 554,288 and 10 / 554,290 (the disclosures of which are incorporated herein by reference) and applied as a topical composition to the surface of skin slices -3) β(1-4) glucan can obviously enter the stratum corneum, epidermis, dermis and subcutaneous tissue layer of the skin. These results demonstrate that the parasiticide encapsulated by β(1-3)β(1-4) glucan isolated according to this method can also efficiently transfer to the dermis and subcutaneous tissue layers of the subject's skin. Therefore, the therapeutic / parasiticidal pharmaceutical compositions of the present invention comprising β(1-3)β(1-4) glucan are advantageous in that they can easily transport ecto- and / or endoparasiticides to The dermis and subcutaneous tissue layers of animal skin.

[0101] The pharmaceutical compositions of the present invention may also contain various known and conventional ...

Embodiment 1

[0135] Preparation method of oat extract

[0136] For each method, 2 or 3 replicates were performed and analyzed.

[0137] Method: Hulled oat kernels (Hinoat variety) were ground through a Willey Mill to pass a 10 mesh screen. To a stirred 50% (v / v) aqueous ethanol solution at 40°C was added a 1:4 (w / v) oatmeal:solvent mix ratio of oatmeal. The resulting mixture was stirred for 30 minutes and then cooled to room temperature. The mixture was then centrifuged at 2830 g for 7 minutes and the supernatant was aspirated. The pellet was resuspended in fresh solvent and centrifuged again. The supernatant was aspirated and the pellet was resuspended a third time in fresh solvent. All supernatants were combined and filtered through coarse sintered glass filters.

[0138] In order to show the difference between the method (process) for preparing the oat extract according to the present invention, which includes the step of adjusting the pH of the extract to <4.0, and the method with...

Embodiment 2

[0165] Scale-up test of oat extraction method

[0166] Method: The hulled oat kernels (AC Ernie variety) were ground through a Willey Mill to pass through a 10 mesh screen. Oatmeal (1.5 kg) was added to a stirred 50% (v / v) aqueous ethanol solution (6000 ml) at 40°C. The resulting mixture was stirred for 30 minutes and then cooled to room temperature. The mixture was then centrifuged at 2830 g for 7 minutes and the supernatant was aspirated. The pellet was resuspended in fresh solvent (3000ml) and centrifuged again. The supernatant was aspirated and the pellet was resuspended a third time in fresh solvent. All supernatants were pooled and filtered through coarse sintered glass filters. The pH of the extract was adjusted to 3.5 with hydrochloric acid (1 M) and ethanol (~1%) was added to clarify the solution. The pale yellow extract was passed through a 0.45 μm filter (Gelman; Supor DCF), made up to 12000 ml, and then ultrafiltered.

[0167] Using Pall Corporation CENTRASET...

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Abstract

Methods and compositions for treating or preventing a skin condition, an inflammation, an irritation or an allergy associated with an ectoparasitic infection or infestation on an animal. The methods involve applying to the skin of the animal a pharmaceutical composition that contains a therapeutically effective amount of one or more than one avenanthramide, an optional ecto and / or endo-parasiticidal agent, and a pharmaceutically acceptable diluent or carrier.

Description

technical field [0001] The present invention relates to pharmaceutical compositions for the treatment of skin diseases or conditions or allergy in animals. More particularly, the present invention relates to pharmaceutical compositions comprising a therapeutically effective amount of one or more avenanthramides for use in the treatment of skin diseases or conditions in animals, and methods of using these compositions. [0002] The present invention relates to the preparation of solubilized liquid oat extract or colloidal oatmeal with formulations useful in the personal care, cosmetic, nutraceutical and pharmaceutical industries. More specifically, the oat extract compositions or colloidal oat flakes of the present invention are useful as anti-irritants, antioxidants and skin protectants applied to the skin or eaten. Background of the Invention [0003] Oat (Avena sativa), especially colloidal oatmeal suspension, has historically been used as an adjuvant in the treatment of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/196A61K36/899A61P17/00A61P29/00A61P33/14
CPCA61K31/196A61K36/899A61P17/00A61P17/04A61P29/00A61P33/00A61P33/10A61P33/14
Inventor D·A·费尔德M·J·雷德蒙德I·W·科特雷尔
Owner CEAPRO
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