Medication application of 4-tert-butyl-5-(1,2,4-triazol-1-yl)-2-benzyliminothiazole

Abstract

The invention discloses a medical application of 4-tert-butyl-5-(1,2,4-triazol-1-yl)-2-benzyliminothiazole as shown in a chemical structural formula (I), wherein the X in the formula (I) is selected from hydrogen, hydroxyl, methoxyl, nitryl, amido and chlorine; the X2 is selected from hydrogen, nitryl, amido, chlorine, bromine and iodine; the X3 is selected from hydrogen, methyl, ethyl, nitryl, methoxyl, chlorine, bromine, amido and dimethylamino; and the X4 is selected from hydrogen, nitryl, amido, chlorine, bromine and iodine. The 4-tert-butyl-5-(1,2,4-triazol-1-yl)-2-benzyliminothiazole has better inhibitory activity to human cervical carcinoma cells, human hepatoma cells, human nasopharyngeal carcinoma cells and the like and can be used for preparing antitumor drugs.

Description

technical field The invention relates to the medical use of a class of compounds, in particular to the medical use of 4-tert-butyl-5-(1,2,4-triazol-1-yl)-2-benziminothiazole. Background technique The patent (CN101602761) describes the preparation and fungicidal activity of 4-tert-butyl-5-(1,2,4-triazol-1-yl)-2-benziminothiazole. There is no research report on the medical use of 4-tert-butyl-5-(1,2,4-triazol-1-yl)-2-benziminothiazole. Contents of the invention The object of the present invention is to provide a kind of medical application of 4-tert-butyl-5-(1,2,4-triazol-1-yl)-2-benziminothiazole represented by chemical structural formula (I). Among them, X in the I formula 1 selected from: hydrogen, hydroxy, methoxy, nitro, amino and chlorine; X 2 selected from: hydrogen, nitro, amino, chlorine, bromine and iodine; X 3 selected from: hydrogen, methyl, ethyl, nitro, methoxy, chlorine, bromine, amino and dimethylamino; X 4 is selected from: hydrogen, nitro, amino, c...

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Problems solved by technology

There are no research reports on the medical use of 4-tert-butyl-5-(1,2,4-triazol-1-yl)-2-benziminothiazole

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