Thiophosphoramides agrochemical and preparation method

Abstract

The invention discloses a thiophosphoramides compound, O,S-dialkyl-N-alkyl-N-(2,2,2-trichloro-1-chloro-ethyl) thiophosphoramide serving as an agrochemical. Active ingredients of the agrochemical serve as insecticides, herbicides and germicides. The structural formula is as shown in the specification: where R1 is CH3, CH2CH3, n-CH2CH2CH3, or isopropyl; R2 is CH3, CH2CH3, n-CH2CH2CH3 or isopropyl; and R3 is H or CH3. The structure is modified by p-methamidophos to reduce the toxicity of the product, increase the activity to the target diseases, insects and weeds and improve the storage stability of the product.

Description

technical field The present invention proposes a thiophosphoramide pesticide O, S-dialkyl-N-alkyl-N-(2,2,2-trichloro-1-chloro-ethyl)thiophosphoramide and its preparation method The compound has insecticidal effect and can replace the highly toxic insecticide methamidophos. The compound is an active substance with insecticidal, bactericidal and herbicidal properties and belongs to the field of agricultural chemicals. Background technique Methamidophos is a broad-spectrum insecticide. Due to its high toxicity to humans, livestock and other mammals, it is a highly toxic pesticide. However, due to its low cost and resistance to pesticides, it is very popular among farmers. In recent years, Due to food safety considerations and international requirements for methamidophos pesticide residues, there is a strong international demand for a complete ban on the production and use of methamidophos pesticides. G·B·Quistad, T·R·Fukuto, R· After studying the analogues of methamidophos, L....

AI Technical Summary

Problems solved by technology

Methamidophos is a broad-spectrum insecticide. Due to its high toxicity to humans, livestock and other mammals, it is a highly toxic pesticide. However, due to its low cost and resistance to pesticides, it is very popular among farmers. In recent years, Due to food safety considerations and international requirements for methamidophos pesticide residues, there is a strong international demand for a complete ban on the production and use of methamidophos pesticides. G·B·Quistad, T·R·Fukuto, R· After studying the analogues of methamidophos, L. Metcalf pointed out that there are substituents on the nitrogen atom of methamidophos, and the toxicity will be reduced; based on this mechanism, Lorenz successfully synthesized acephate in 1964, and in 1971 It was first introduced as an experimental product by Chevron Corporation of the United States in 1999, and it was put into industrial production and promotion. Its effective period is 10-15 days, and it is especially effective for Lepidoptera, Hemiptera, Homoptera and Coleoptera insects. The toxicity is low, and the toxicity to poultry and fish is also very low, but there is a disadvantage that the use effect is also significantly reduced while the toxicity is reduced

Chinese patent ZL97112828.6 discloses a new compound O, S-dialkyl-N-alkyl, which not only contains a complete methamidophos structure, but also has better efficacy against resistant insects than methamidophos, and is less toxic to humans. -N-(2,2,2-trichloro-1-hydroxyl-ethyl) phosphorothioate, the structural formula is: CH 3 S(CH 3 O)P(O)NHCHOHC-Cl 3 , it not only retains the toxic action mode of methamidophos on insects, but also has fumigating properties. At the same time, it can also be made into various dosage forms and has been put into production. This product cannot be stored, which is the fatal shortcoming of this product

Chinese patent ZL02148427.9 has modified the structure of methamidophos and introduced a series of fluorine-containing acylation structures, but due to the high cost, there are also defects in industrial production

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