Bufogenin compound and application thereof in preparing anti-tumor medicaments

Abstract

The invention relates to a bufogenin compound and an application thereof in preparing anti-tumor medicaments. The bufogenin compound comprises cinobufagin and derivatives thereof, contains pharmaceutically acceptable salts thereof, has a chemical structural formula which is shown in the specification, wherein groups R1, R2, R3 and R4 are respectively selected from hydrogen, halogens, C1-C6straight chain or branch chain saturated or unsaturated alkyls, C3-C7 ring alkyls, benzyls, aromatic groups or 5-7-tuple heterocyclic groups. Proved by in-vitro cellular experiments, the compound can remarkably inhibit the proliferation of liver cancer and lung cancer cells and accordingly can be used for preparing medicaments for inhibiting tumor growth.

Description

Technical field The invention relates to the technical field of medicine, and is a bufarolactone compound and its application in preparing antitumor drugs. The bufarolactone compound refers to bufostinol and its derivatives, including its pharmaceutically acceptable salts. Background technique There are more than 250 species of toads, distributed all over the world. There are nearly 10 species in our country, the main three are: toad Huaxia, Bufo subspecies sinensis and Black-eyed toad. The ancient prescriptions are widely used in toads to remove toxins and reduce swelling, to determine ketones to kill insects, and to strengthen the heart and diuresis. At present, toad venom analgesic ointment, toad venom injection, cinocabine injection and compound toad skin capsules are used in clinical anti-tumor, analgesic, swelling and swelling, and enhancement of body immunity. Toad preparations have the advantages of treating both symptoms and root causes in clinical adjuvant treatmen...

AI Technical Summary

Problems solved by technology

However, the current toad preparations all use crude extracts as medicines, and the ingredients are extremely complex. In addition to bufagenin, bufotoxin, and indole alkaloids, they also contain amino acids, reducing sugars, steroids, peptides, etc. types of chemical constituents

Therefore, in clinical use, the toad preparation has the following two main disadvantages: the killing rate of tumor cells is low; allergic reactions occur

So far, there is no report on the use of cinobufaginol and its derivatives in the preparation of tumor growth inhibitory drugs

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