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Composition for treating menopause syndrome and preparation method thereof

A technology of composition and syndrome, applied in the field of pharmaceutical composition and preparation thereof, can solve the problems of inconvenient use, poor quality controllability, backward dosage form and the like

Inactive Publication Date: 2010-09-08
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In recent years, there have been clinical methods to treat this disease with prescriptions guided by the theory of traditional Chinese medicine, and some results have been achieved. However, these prescriptions are mainly decoctions, with backward dosage forms, poor quality controllability, and inconvenient use.

Method used

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  • Composition for treating menopause syndrome and preparation method thereof
  • Composition for treating menopause syndrome and preparation method thereof
  • Composition for treating menopause syndrome and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Prescription: Curculigo 750g, Epimedium 750g, Morinda officinalis 750g, Cinnamon 333g, Rehmannia glutinosa 1250g, Scrophulariae 1250g, Phellodendron 1000g, Anemarrhena 1000g, Codonopsis 1000g, Stir-fried Atractylodes macrocephala 1000g, Poria cocos 2083g, Fushen 2083g, Coptis 417g , lotus seed heart 417g, uncaria 1333g, purple shellfish 1250g, peony bark 1250g, floating wheat 2917g.

[0067] (equivalent to 9:9:9:4:15:15:12:12:12:12:25:25:5:5:16:15:15:35)

[0068] Preparation method: take Epimedium, pulverize, add 80% ethanol with 8 times the volume of its weight, reflux and extract twice, each time for 1.5 hours, combine the reflux liquid, filter, recover ethanol under reduced pressure to the end, and obtain Epimedium water liquid, set aside; take cinnamon, extract volatile oil by steam distillation, get cinnamon volatile oil, set aside; take Curculigo, Morinda officinalis, Rehmannia glutinosa, Scrophulariaceae, Cortex Phellodendri, Anemarrhena, Codonopsis, Stir-fried A...

Embodiment 2

[0075] Prescription: Curculigo 1250g, Epimedium 1250g, Morinda officinalis 1250g, cinnamon 83g, Rehmannia glutinosa 750g, Scrophulariae 750g, Phellodendron 500g, Anemarrhena 500g, Codonopsis 500g, Stir-fried Atractylodes macrocephala 500g, Poria 1500g, Poria 1500g, Coptis 167g , lotus seed heart 167g, uncaria 1083g, purple shellfish 833g, peony bark 833g, floating wheat 2083g.

[0076] (equivalent to 15:15:15:1:9:9:6:6:6:6:18:18:2:2:13:10:10:25)

[0077] Preparation method: with embodiment 1.

[0078] Usage: 2 times a day, 6 capsules each time

[0079] Pharmacological test: With reference to Test Example 2, the test results are shown in the following table:

[0080] Table 4 The influence (n=12, )

[0081]

[0082] The test results show that, compared with the castration group, the serum estradiol (E2) concentration of rats with the composition of the present invention is significantly increased, and has a significant significance (p<0.05).

Embodiment 3

[0084] Prescription: Curculigo 1250g, Epimedium 1250g, Morinda officinalis 1250g, cinnamon 83g, Rehmannia glutinosa 1250g, Scrophulariaceae 1250g, Phellodendron 1000g, Anemarrhena 1000g, Codonopsis 1000g, Fried Atractylodes macrocephala 1000g, Poria cocos 2083g, Fushen 2083g, Coptis 417g , lotus seed heart 417g, uncaria 1333g, purple shellfish 1250g, peony bark 1250g, floating wheat 2917g.

[0085] (equivalent to 15:15:15:1:15:15:12:12:12:12:25:25:5:5:16:15:15:35)

[0086] Preparation method: with embodiment 1.

[0087] Usage: 2 times a day, 6 capsules each time

[0088] Pharmacological test: With reference to Test Example 2, the test results are shown in the following table:

[0089] Table 5 The influence (n=12, )

[0090]

[0091] The test results show that, compared with the castration group, the serum estradiol (E2) concentration of rats with the composition of the present invention is significantly increased, and has a significant significance (p<0.05).

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Abstract

The invention relates to a composition for treating a menopause syndrome, which is prepared from the following raw materials in parts by weight: 9 to 15 parts of curculigo orchioides, 9 to 15 parts of epimedium, 9 to 15 parts of morinda officinalis, 1 to 4 parts of cinnamon, 9 to 15 parts of radix rehmanniae recen, 9 to 15 parts of figwort, 6 to 12 parts of phellodendron, 6 to 12 parts of rhizoma anemarrhenae, 6 to 12 parts of radix codonopsitis, 6 to 12 parts of rhizoma atractylodis macrocephalae, 18 to 25 parts of tuckahoe, 18 to 25 parts of poria with hostood, 2 to 5 parts of rhizoma coptidis, 2 to 5 parts of plumula nelumbinis, 13 to 16 parts of uncaria, 10 to 15 parts of Arabic cowry shell, 10 to 15 parts of tree peony bark and 25 to 35 parts of blighted wheat. The composition has reasonable formula and exact curative effect for treating the menopause syndrome. The invention also relates to a preparation method of the composition, which comprises the following steps: carrying out alcohol extraction of the epimedium, extracting volatile oil from the cinnamon, carrying out water boiling and alcohol deposition for other medicines, mixing, and adding an adjuvant material to prepare a pharmaceutically acceptable preparation. Convenient use and controllable quality of the composition can be ensured by preparing through the method.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a composition composed of traditional Chinese medicines and a preparation method thereof. Background technique [0002] Climacteric Syndrome (Climacteric Syndrome) refers to a series of symptoms in menopausal women. Common symptoms include hot flushes, irritability, insomnia, forgetfulness, dizziness, headache, low back pain, and osteoporosis. Menopausal syndrome is also called perimenopausal syndrome, which is equivalent to "all syndromes before and after menstruation" in traditional Chinese medicine. [0003] Due to the decline of ovarian function in menopausal women, the level of estrogen in the body gradually decreases, often accompanied by a series of symptoms, such as hot flashes, night sweats, palpitation, shortness of breath, sore limbs, insomnia, forgetfulness, etc.; at the same time, weight gain, waist circumference increase, central obesi...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P15/12
Inventor 陈斌贾晓斌陈彦韦英杰
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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