Substituted sulphonamide compound and preparation method, medicine composition and application thereof

Abstract

The invention relates to substituted sulphonamide compound and preparation method, medicine composition and application thereof, in particular provides the substituted sulphonamide compound shown in general formula (I) or pharmaceutically acceptable salt thereof, Ar, X, Y, Z and R are defined in the specification. The compound has good preventing and treating effect on diseases mediated by GPR40 such as diabetes, breast cancer and certain nerve disease. The compound is GTP bonding protein ion-channel-linked receptor 40 antagonist. Thus, the compound is hopeful to be developed into novel medicine for treating diabetes and the like. The invention also provides the preparation method and medicine composition of the compound.

Description

technical field The present invention relates to the fields of medicinal chemistry and pharmacotherapeutics, in particular to substituted sulfonamide compounds, their preparation methods, applications and pharmaceutical compositions containing such compounds. Background technique Diabetes has become the third chronic non-communicable disease that seriously threatens human health after tumors and cardiovascular diseases, and is an increasingly serious public health problem. According to the latest authoritative data released by the World Health Organization (WHO), the incidence of diabetes in the world has increased rapidly in recent years. The number of patients with the disease has exceeded 177 million and is expected to reach 370 million by 2025. The severe situation of diabetes in China is even more thought-provoking. As of 2003, China has become the second largest country with diabetes, with 23.8 million diabetics, second only to India. It is estimated that by 2030, t...

AI Technical Summary

Problems solved by technology

However, the GPCR family is a type of transmembrane receptor, and the technical limitations of crystallography make it very difficult to determine the three-dimensional structure of this type of membrane protein

Although some institutions may have determined the three-dimensional structure of some GPCR proteins, so far, there are very few GPCR members whose three-dimensional structures have been successfully resolved

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