Culture medium for producing griseofulvin by fermentation

Abstract

The invention discloses a culture medium for producing fermentation by fermentation, which comprises a seed culture medium and a fermentation medium. In the process of fermentation culture, when total sugar reduces to 2.0-3.0%, a feed supplement culture medium is added; and corn is used as a main carbon source to prepare the fermentation culture medium. Preferentially, the seed culture medium and the feed supplement culture medium are also prepared by using the corn as the main carbon source. Since the price of corn flour is much lower than that of rice flour, the production cost is greatly reduced; in addition, the corn flour has sufficient supply and stable quality, thereby ensuring the stability of fermentation production.

Description

Medium for fermentative production of griseofulvin technical field The invention belongs to the technical field of microbial fermentation engineering, and in particular relates to a culture medium for fermenting and producing griseofulvin. Background technique Griseofulvin (griseoflvin) belongs to the antibiotic of aromatic derivatives, is an antifungal antibiotic, mainly treats the infection caused by dermatophytes, and is used in agriculture to resist plant fungal diseases. The domestically produced bacteria used in the fermentation production of griseofulvin are obtained from the wild Penicillumpatulum 4541 strain selected by my country through multiple generations of mutagenesis and directional selection, and the strain used in the present invention is also a descendant of this strain. Since the industrial fermentation production of griseofulvin in the 1880s, indica rice flour (or called rice flour) processed from indica rice abounds in the south has been used as the m...

AI Technical Summary

Problems solved by technology

Rice is used as the main carbon source to produce griseofulvin. The supply of goods is insufficient, the quality of raw materials is not guaranteed, and the production cost is high