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Use of total flavonoids from radix Daphne genkwa in preparing weight-losing hypolipemic drugs

A blood lipid-lowering drug and total flavonoid technology, which is applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., to achieve the effect of low production cost, simple method and high total flavonoid content

Inactive Publication Date: 2010-08-18
西藏自治区高原生物研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the published methods for the development and utilization of fennel root, there is no report on the efficacy of total flavonoids in fennel root for weight loss and blood fat reduction.

Method used

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  • Use of total flavonoids from radix Daphne genkwa in preparing weight-losing hypolipemic drugs
  • Use of total flavonoids from radix Daphne genkwa in preparing weight-losing hypolipemic drugs
  • Use of total flavonoids from radix Daphne genkwa in preparing weight-losing hypolipemic drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Using method A, take the sun-dried coriander root and crush it to 100 mesh, boil it with 5 times the volume of distilled water, and slowly add NaOH while stirring continuously after boiling to adjust the pH of the solution to 10. Continue to keep boiling for 20min. While hot, use four layers of gauze pads to carry out suction filtration on the Buchner funnel, and filter the filtrate again with medium-speed filter paper after the suction filtration. Collect the filtrate. The filter residue was decocted again with 5 times the volume of distilled water for 20 minutes, suction filtered and filtered, and the filter residue was repeatedly extracted 3 times in this way, and the filtrates were combined. Heat the filtrate to 60°C, slowly add concentrated hydrochloric acid, adjust the pH of the solution to 4, stir evenly, let stand for 24 hours, and filter with suction to collect the precipitate. The precipitate was washed with a large amount of distilled water until the pH was...

Embodiment 2

[0038] Using method A, take the sun-dried coriander root and crush it to 40 mesh, boil it with 15 times the volume of distilled water, slowly add milk of lime while stirring continuously after boiling, and adjust the pH of the solution to 9. Continue to keep boiling for 60min. While hot, use four layers of gauze pads to carry out suction filtration on the Buchner funnel, and filter the filtrate again with medium-speed filter paper after the suction filtration. Collect the filtrate. The filter residue was decocted again with 15 times the volume of distilled water for 60 minutes, suction filtered and filtered, and the filter residue was extracted once more in this way, and the filtrates were combined. Heat the filtrate to 80°C, slowly add concentrated hydrochloric acid, adjust the pH of the solution to 4, stir evenly, let stand for 24 hours, and filter with suction to collect the precipitate. The precipitate was washed with a large amount of distilled water until the pH was 7,...

Embodiment 3

[0040] Using method A, take the sun-dried coriander root and crush it to 200 mesh, boil it with 10 times the volume of distilled water, and slowly add milk of lime while stirring continuously after boiling, and adjust the pH of the solution to 8. Continue to keep boiling for 40min. While hot, use four layers of gauze pads to carry out suction filtration on the Buchner funnel, and filter the filtrate again with medium-speed filter paper after the suction filtration. Collect the filtrate. The filter residue was decocted again with 5 times the volume of distilled water for 40 minutes, suction filtered and filtered, and the filter residue was extracted twice in this way, and the filtrate was combined. Heat the filtrate to 70°C, slowly add concentrated hydrochloric acid, adjust the pH of the solution to 4, stir evenly, let stand for 24 hours, and then filter with suction to collect the precipitate. The precipitate was washed with a large amount of distilled water until the pH was...

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Abstract

The invention relates to a use of total flavonoids from radix Daphne genkwa plants in preparing weight-losing hypolipemic drugs, especially weight losing, which achieves the purpose of losing weight and simultaneously can lower the content of TC, TG and LDL-C and raise the content of HDL-C.

Description

technical field [0001] The invention relates to the use of the total flavonoids extracted from the root of the root of the root of the root to prepare weight loss and blood fat lowering medicine, and belongs to the field of medicinal natural products. Background technique [0002] Obesity itself is a chronic disease that threatens human health, and it is also accompanied by hyperlipidemia, cardiovascular and cerebrovascular diseases. At present, obesity has become one of the health problems of global concern. Therefore, research and development of safe and effective weight loss and blood fat reduction Medicine has great clinical and social significance. [0003] Coriander root (Brassica rapa L.), also known as Manjing, is a biennial herb that is widely planted on the Qinghai-Tibet Plateau. Coriander root grows in the plateau environment with high altitude, large temperature difference and strong sunshine. It has strong adaptability, high yield and rich nutrition. It is usua...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/31A61P3/04A61P3/06A61K125/00
Inventor 蒋思萍高平
Owner 西藏自治区高原生物研究所
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