Pharmaceutical composite for treating cerebral stroke, preparation method and application thereof
A composition and stroke technology, applied in the field of medicine, to achieve the effect of reducing the volume of cerebral infarction, controllable quality, and clear drug effect
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Embodiment 1
[0027] The preparation of embodiment 1 medicine of the present invention:
[0028] a. Astragalus decoction pieces are extracted with 30% ethanol, the filtrate is passed through a macroporous resin column, eluted with 30% ethanol, and the ethanol is recovered to obtain total saponins of Astragalus;
[0029] B, the preparation of Danshen ethanol extract: Danshen decoction pieces are heated and extracted with 8 times of water, and the extract is passed through a macroporous resin column (D 101 ), eluted with 50% ethanol, reclaimed ethanol, and obtained salvia miltiorrhiza phenolic acid; dregs were recovered and extracted with 95% ethanol, recovered ethanol, obtained salvia miltiorrhiza ketone extract, mixed salvia miltiorrhiza total phenolic acid and salvia miltiorrhiza total ketone extract, obtained Danshen alcohol extract;
[0030] c, the decoction pieces of Chuanxiong are extracted with 80% ethanol solvent, and the solvent is recovered to obtain Chuanxiong oil;
[0031]d. Th...
Embodiment 2
[0032] The preparation of embodiment 2 medicines of the present invention
[0033] a. Astragalus decoction pieces are extracted with 60% ethanol, the filtrate is passed through a macroporous resin column, eluted with 70% ethanol, and the ethanol is recovered to obtain total saponins of Astragalus;
[0034] b. Preparation of the alcoholic extract of Salvia miltiorrhiza: extract by heating the decoction pieces of Salvia miltiorrhiza with 15 times of water, pass the extract through a macroporous resin column, elute with 90% ethanol, recover the ethanol, and obtain the total phenolic acid of Salvia miltiorrhiza; recover and extract the dregs with absolute ethanol, recovering ethanol to obtain the total ketone extract of salvia miltiorrhiza, mixing the total phenolic acids of salvia miltiorrhiza with the total ketone extract of salvia miltiorrhiza to obtain the ethanol extract of salvia miltiorrhiza;
[0035] c, the decoction pieces of Chuanxiong are extracted with absolute ethanol...
Embodiment 3
[0037] Embodiment 3 preparation of medicine of the present invention
[0038] Take 6 kg of total astragalus saponins prepared in Example 1, 2.5 kg of alcoholic extract of Salvia miltiorrhiza and 3 kg of Chuanxiong oil, mix them, and prepare tablets according to the method in Example 1.
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