Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Animal pancreatic extract for preventing and curing diabetes

An extract, diabetes technology, applied in metabolic diseases, drug combinations, medical preparations containing active ingredients, etc., can solve the problems of lack of protection, small toxic and side effects, etc.

Inactive Publication Date: 2013-01-23
陈光明
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is still a lack of drugs that protect pancreatic β-cells, promote β-cell regeneration and repair, delay or reverse the severity of diabetes, and have less toxic side effects

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Animal pancreatic extract for preventing and curing diabetes
  • Animal pancreatic extract for preventing and curing diabetes
  • Animal pancreatic extract for preventing and curing diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: Extraction and identification of small-molecule peptides from piglet pancreas

[0024] 1. Raw materials

[0025] Animals: Hybrid pigs, pigs aged about 20 weeks, slaughtered in a legal slaughter plant, with animal product quarantine certificate. The collection and transportation of raw materials are processed at a low temperature of 20-25°C.

[0026] 2. Pancreatic quality control:

[0027] 2.1 Weight: Complete piglet pancreas (with a small amount of fatty tissue), with an average weight of 120±30 grams.

[0028] 2.2 Appearance and traits: The pancreas has a smooth surface, fresh color, off-white, no peculiar smell, no nodules, and no abnormal profile.

[0029] 2.3 Determination of volatile basic nitrogen: randomly sample pig pancreas at a rate of 1%, cut 10g from each pancreas, and carry out limited detection according to the national standard GB / TS009.44-2003 trace diffusion method to check volatile basic nitrogen. The national standard GB16869-2005 ensures the freshn...

Embodiment 2

[0037] Example 2: The effect of the animal pancreas extract of the present invention on the animal model of diabetes

[0038] 1. Rat diabetes model

[0039] Material: Wistar rat, male, 200±10g, purchased from Experimental Animal Center of Southern Medical University

[0040] Reagents and equipment: streptozotocin (STZ, Sunland Company, USA); micro blood glucose meter (Model 5D-2, Beijing Yicheng Bioelectronics Technology Co., Ltd.); animal weighing electronic balance (G&G, USA).

[0041] Method: Receive qualified Wistar rats, adaptively raise them for one week, fast overnight, fasting and intraperitoneal injection of STZ (30mg / kg) to create models (Method reference: Li Cai, editor, reproduction of human disease animal models, People's Health Publishing Society, first edition in 2008; Diabetes animal model, p345.). One week after STZ injection, random blood glucose was detected, and those with more than 16.7mmol / L were selected as diabetic rats. In diabetic rats without intervention,...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to an animal pancreatic extract and a medicinal purpose of the animal pancreatic extract. In the invention, the animal pancreatic extract for preventing and curing diabetes is an active substance solution which is extracted from the fresh pancreas of a young pig and has small molecular weight not more than 10000 Daltons, the extraction liquid is supernatant liquid, the pH value of which is 6.0-7.0, and each 1ml of the extraction liquid contains not less than 15mg of polypeptide and does not contain insulin. The animal pancreatic extract of the invention is an active polypeptide substance with small molecular weight, which is obtained by taking the organ pancreas which causes the diabetes as a target spot, selecting the animal pancreas as a raw material and using the modern technology for extracting. The animal pancreatic extract of the invention is suitable for preventing and curing various types of diabetes, curing severe diabetes, preventing levis diabetes fromworsening, preventing organ posttransplantation diabetes, reducing adverse reaction of anti-rejection drugs, reversing or delaying the occurrence and the development of the severe diabetes, and preventing various complications of diabetes.

Description

Technical field [0001] The invention belongs to the field of biotechnology, and relates to an animal pancreas extract and the pharmaceutical use of the animal pancreas extract. Background technique [0002] Diabetes is a group of metabolic diseases characterized by increased blood glucose levels. Diabetes has become a major disease that affects the physical and mental health of Chinese people due to its high harm, difficult to cure, and high cost. The predisposing factors of diabetes include genetics, viral infections, autoimmunity, organ transplantation, dietary factors, and bad moods. [0003] The incidence of diabetes is getting higher and higher. At present, there are about 180 million diabetes patients worldwide. Experts predict that it will exceed 300 million by 2025, of which 75% are in developing countries such as India and China. According to statistics, the incidence of diabetes in the world is 3% to 5%, and the incidence rate per person over the age of 50 is 10%. Most...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/39A61P3/10
Inventor 陈光明王洪敏饶桂荣张海松杨富强莫国玉
Owner 陈光明
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com