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Preparation method of qingkailing syrup

A technology for syrup and paste clearing, applied in the field of syrup and its preparation, can solve the problem of low extraction rate of active ingredients, achieve significant curative effect, increase content, and inhibit production and release

Active Publication Date: 2012-03-14
哈尔滨一洲制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by the present invention is to provide a Qingkailing syrup and a preparation method thereof in order to solve the problem that the extraction rate of active ingredients is not high in the existing process of preparing Qingkailing oral liquid

Method used

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  • Preparation method of qingkailing syrup
  • Preparation method of qingkailing syrup
  • Preparation method of qingkailing syrup

Examples

Experimental program
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Effect test

specific Embodiment approach 1

[0015] Embodiment 1: In this embodiment, Qingkailing syrup mainly consists of 1.3g cholic acid, 1.5g hyodeoxycholic acid, 20g mother-of-pearl powder, 10g buffalo horn powder, 35g honeysuckle, 10g gardenia, 80g isatidis, 2g baicalin , 5-100g β-cyclodextrin, 450-800g sucrose, 0.1-0.5g ethylparaben, 0.1-0.5g propylparaben and 0.5-50mL essence.

[0016] The preparation method of Qingkailing syrup in this embodiment is as follows: 1. Add 10g gardenia and 80g Radix Radix to 400ml-2000ml water and decoct for 1.5 hours, filter, then add the filter residue to 400ml-2000ml water and decoct for 1 hour, filter , combine the filtrates filtered twice, then concentrate the filtrate to a clear paste with a relative density of 1.05 to 1.20, then add ethanol until the volume concentration of ethanol is 60%, leave it for 12 to 24 hours, filter, and recover the ethanol in the filtrate under reduced pressure , and then the filtrate is concentrated to a relative density of 1.05 to 1.40 gardenia and...

specific Embodiment approach 2

[0038] Specific embodiment two: the difference between this embodiment and specific embodiment one is that the essence is orange flavor essence. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0039] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is that in step one, the filtrate is concentrated to a clear paste with a relative density of 1.20. Others are the same as in the first or second embodiment.

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Abstract

The invention provides qingkailing syrup and a preparation method thereof, which relate to a pure traditional Chinese medicine preparation. The invention solves the problem of low extraction rate of effective components in the traditional process of preparing qingkailing oral liquid. The qingkailing syrup comprises cholic acid, hyodesoxycholic acid, mother-of-pearl powder, buffalo horn powder, honeysuckle, gardenia, radix isatidis, baicalin, beta-schardinger dextrin, sucrose, ethylparaben, propyl p-hydroxybenzoate, essence and water. The preparation method of the qingkailing syrup comprises the following steps: dissolving a clear paste of the gardenia and the radix isatidis, a clear paste of the honeysuckle, the inclusion powder of a buffalo horn and mother-of-pearl and the inclusion powder of the cholic acid and hyodesoxycholic acid into water for wetting, adding single syrup, stirring evenly, boiling, then adding a baicalin solution, an essence solution and a preservative solution, afterwards adding the water, fixing the volume to 1000ml, stirring evenly, standing, filtering and filling so as to obtain the qingkailing syrup. In the process of preparing the qingkailing syrup, theinvention enhances the content of the effective components of the radix isatidis, the gardenia, the honeysuckle, the buffalo horn and the mother-of-pearl.

Description

technical field [0001] The invention relates to a pure traditional Chinese medicine preparation, in particular to a syrup and a preparation method thereof. Background technique [0002] Qingkailing injection, oral liquid, granules, capsules, and tablets have the disadvantages of inconvenient medication, bad taste (bitter, fishy, ​​and smelly), long disintegration time, and slow absorption. In the preparation process of Kailing Oral Liquid, the combination of Banlangen, Gardenia and Honeysuckle is usually used to decoct the three herbs, and the active ingredients of buffalo horn and mother-of-pearl are extracted by acid hydrolysis. The extraction rate is not high. Contents of the invention [0003] The technical problem to be solved by the present invention is to provide a Qingkailing syrup and a preparation method thereof in order to solve the problem of low extraction rate of active ingredients in the existing process of preparing Qingkailing oral liquid. [0004] Qingk...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61P11/14A61K9/00A61K31/575A61P11/02A61P25/20A61K31/7048A61P11/04A61K36/744A61P29/00A61P25/04A61K35/56A61P11/00A61K35/32A61K35/618
Inventor 张宏王栗张贵伍张凤敏
Owner 哈尔滨一洲制药有限公司
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