Composition for treating and/or preventing gastric ulcer and use thereof

A composition, a technology for gastric ulcer, applied in the active ingredient composition for treating gastric ulcer, treating and/or preventing the symptoms of gastric ulcer in an individual, and being able to solve the problems of not treating and preventing gastric ulcer and the like

Active Publication Date: 2012-06-27
THE CHINESE UNIVERSITY OF HONG KONG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, none of these herbs have been used individually to treat and prevent gastric ulcer conditions

Method used

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  • Composition for treating and/or preventing gastric ulcer and use thereof
  • Composition for treating and/or preventing gastric ulcer and use thereof
  • Composition for treating and/or preventing gastric ulcer and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0025] Materials and Methods

[0026] Material

[0027] Indomethacin, ethanol, sodium chloride, berberine, formalin were purchased from sigma-Aldrich (St. Louis, MO). The Chinese medicine decoction pieces Coptidis Coptidis and Corydalis Corydalis used in the experiment were all purchased from Chinese herbal pharmacies. All other materials and reagents used in the experiments were of analytical grade. The plant compound (extract) was dissolved in double distilled water to prepare different concentrations (for example, 6.25mg / mL, 12.5mg / mL, 20mg / mL, 25mg / mL, 50mg / mL, and 100mg / mL, 200mg / mL, etc. ). Indomethacin dissolved in 5% NaHCO 3 Prepare a solution with a concentration of 8 mg / ml.

[0028] animal

[0029] Sprague-Dawley (SD) rats (180-200 g) were from Laboratory Animal Services Centre, CUHK. They were provided with a 12-h light / dark cycle by the center's technicians and given ad libitum commercial mouse chow and water.

[0030] Extracting berberine from berberine

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PUM

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Abstract

The invention discloses a medicament composition for treating and / or preventing individual gastric ulcer disease or illness, which contains active components with effective amount for treating and pharmaceutically acceptable carrier, wherein the active components are selected from berberine in coptis root and corydalis B in corydalis ambigua, or their pharmaceutically acceptable salt; as well as the use of medicament composition. The invention also discloses a method for treating and / or preventing individual gastric ulcer disease or illness, and the method includes steps for giving the composition disclosed in the invention to individual.

Description

technical field [0001] The present invention relates to treating and / or preventing gastric ulcer symptoms in an individual. In particular, the present invention relates to active ingredient compositions for the treatment of gastric ulcer conditions and methods of preparation and use of said compositions. The composition can be used as an adjunct in the treatment of gastric ulcer in humans. Background of the invention [0002] Gastric ulcer is a benign gastric mucosal injury in which epithelial cells are exposed to acid and nonsteroidal anti-inflammatory drugs (NSAIDs). It is a digestive disorder that is triggered by stress, indulgence, and anxiety. Stomach ulcer conditions occur in all age groups and affect both men and women. It is estimated that approximately 10% of the population develops gastric ulcer symptoms due to acid secretion and defense mechanisms of the mucosal epithelium. The increased incidence of gastric ulcers with age may be related to the gradual inabil...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4375A61P1/04
Inventor 何永成
Owner THE CHINESE UNIVERSITY OF HONG KONG
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