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Method for preparing ceftiofur hydrochloride parenteral solution

A technology of ceftiofur hydrochloride and injection, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve the problems of uneven injection, easy stratification, inconvenient use, etc. , to achieve the effect of overcoming easy stratification, solving injection difficulties, and solving uneven injection

Inactive Publication Date: 2009-12-16
上海恒丰强生物技术有限公司
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AI Technical Summary

Problems solved by technology

The invention solves the problem of difficult injection and uneven injection of the ceftiofur hydrochloride injection in the prior art, and makes up for the inconvenient use of the ceftiofur hydrochloride suspension injection in the prior art because it is easy to stratify

Method used

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Embodiment Construction

[0015] The present invention will be further described below in combination with specific embodiments. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. In addition, it should be understood that after reading the teachings of the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalent forms also fall within the scope defined by the appended claims of the present application.

[0016] A kind of preparation method of ceftiofur hydrochloride injection of the present invention is a kind of preparation method of uniformly distributed, clear and transparent ceftiofur hydrochloride injection, comprising the following steps:

[0017] (1) Add propylene glycol and ceftiofur hydrochloride of 60% to 70% of the total volume of the prepared ceftiofur hydrochloride injection in the concentrated preparation t...

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Abstract

The invention relates to a method for preparing ceftiofur hydrochloride parenteral solution; the hydrochloride parenteral solution has the characteristics of even distribution and clear and transparent solution. The method comprises the following steps: (1) adding propylene glycol and ceftiofur hydrochloride with a volume equal to 60-70% of the total volume of ceftiofur hydrochloride parenteral solution to be prepared in a thick mixing tank; adding 2-10g ceftiofur hydrochloride for every 100ml of total volume of the ceftiofur hydrochloride parenteral solution; heating to 40-50 DEG C and stirring for rapid dissolving; (2) adding propylene glycol to reach the total volume of the ceftiofur hydrochloride parenteral solution to be prepared and cooling to 20-30 DEG C; (3) adding active carbon, stirring for 15-20 minutes and filtering; and (4) filling and sealing, sterilizing, light check and packing. The invention solves the problems of difficult and uneven injection of the ceftiofur hydrochloride parenteral solution of the existing technology and makes up the defects of easy-layer and inconvenient use of the ceftiofur hydrochloride suspension injection of the existing technology.

Description

technical field [0001] The invention relates to a preparation method of ceftiofur hydrochloride injection, in particular to a preparation method of uniformly distributed, clear and transparent ceftiofur hydrochloride injection. Background technique [0002] Porcine contagious pleuropneumonia is a respiratory infectious disease caused by Actinobacillus pleuropneumoniae. Acute and subacute cases are mainly characterized by fibrinous hemorrhagic pleuropneumonia, and chronic cases are mainly characterized by fibrinous necrotizing pleuropneumonia. In the past 20 years, the disease has been increasing year by year in the world, and has become one of the main infectious diseases of pigs, which has brought huge losses to the breeding industry. Ceftiofur hydrochloride has a strong antibacterial effect on most Gram-negative and positive bacteria. It is effective against diseases caused by various pathogens such as Pasta bacillus multocida, Paste bacillus haemolytica, Actinobacillus p...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/546A61K47/10A61P31/04
Inventor 龙谭廖洪程明镜郭春艳
Owner 上海恒丰强生物技术有限公司
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