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Application of carbomer gel in prevention of allergic rhinitis

A technology for allergic rhinitis and gel, applied in the field of water-soluble polymer pharmaceutical excipients carbomer, can solve the problems of large side effects, high cost, liver damage and the like

Inactive Publication Date: 2009-12-02
郭进军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2. Hormone therapy. Oral hormone therapy is also commonly used in hospitals. It is very effective in treating allergic diseases, but the side effects are too large to be used frequently. It can only be temporarily controlled when the condition is severe. Commonly used hormones can seriously damage the liver and kidneys, etc. internal organs
3. Desensitization treatment, the allergens that cause allergic rhinitis are made into extracts, which are gradually increased from small doses to large doses and injected repeatedly. This method enhances the patient's ability to adapt to allergens. The disadvantage is that the course of treatment is long and the cost is high. , the effective rate is only about 30%

Method used

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  • Application of carbomer gel in prevention of allergic rhinitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Prescription: Carbomer 3g (medicinal oral grade 934P); xylitol 80g (injection grade); sodium bicarbonate appropriate amount (pharmaceutical grade); peppermint oil 0.1ml (pharmaceutical grade); 1000ml

[0027] Preparation process: Precisely weigh 3g of carbomer, disperse it in about 600ml of pure water and swell for 24 hours, then add an appropriate amount of sodium bicarbonate to adjust the pH value to 6.0-7.0. In addition, dissolve xylitol and peppermint oil with an appropriate amount of pure water, and slowly add to the upper liquid, add pure water to 1000ml, stir well to obtain a transparent carbomer gel.

Embodiment 2

[0029] Prescription: Carbomer 3g (medicinal oral grade 934P); glycerin 40g (injection grade); triethanolamine appropriate amount (pharmaceutical grade); peppermint oil 0.1ml (pharmaceutical grade); the balance is purified water to 1000ml

[0030] Preparation process: Precisely weigh 3g of carbomer, disperse it in about 600ml of pure water and swell for 24 hours, then add an appropriate amount of triethanolamine to adjust the pH value to 6.0-7.0. In addition, dissolve glycerin and peppermint oil with an appropriate amount of purified water, and slowly add to the upper liquid, add purified water to 1000ml, stir well to obtain transparent Carbomer Gel II.

Embodiment 3

[0032] Prescription: Carbomer 4g (medicinal oral grade 934P); appropriate amount of sodium hydroxide solution (pharmaceutical grade); peppermint oil 0.1ml (pharmaceutical grade); ethylparaben 0.3g; 1000ml

[0033] Preparation process: Precisely weigh 4g of carbomer, disperse it in about 600ml of pure water and swell for 24 hours, then add an appropriate amount of sodium hydroxide solution to adjust the pH value to 6.0-7.0. In addition, dissolve ethylparaben and peppermint oil with an appropriate amount of warm purified water, and slowly add to the upper liquid, add purified water to 1000ml, stir well to obtain transparent Carbomer Gel III.

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PUM

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Abstract

The invention discloses a method for preparing carbomer gel and an application thereof in allergic rhinitis. The invention provides a concrete method for preparing gel by using carbomer, flavouring peppermint oil and a neutralizing agent, such as sodium bicarbonate. The invention discovers and proves that the carbomer gel which is smeared on the mouths of nasal cavities can adsorb allergic substances, such as pollen, dust mites, and the like, and can prevent and lighten the generation of perennial and seasonal allergic rhinitis.

Description

[0001] Field [0002] The invention relates to the application of a water-soluble polymer pharmaceutical auxiliary material carbomer in the prevention of allergic rhinitis, and relates to a preparation method of the gel and a use method for preventing allergic rhinitis. Background technique [0003] Inhalational allergens are the main factors causing allergic rhinitis, including: 1. Pollen 2. Indoor and outdoor dust 3. Dust mites 4. Fungi 5. Animal fur 6. Feathers 7. Cotton wadding, etc. When the body comes into contact with these allergens, the body will produce IgE antibodies, which will be adsorbed on the surface of tissue mast cells and basophils, and the body is in an sensitized state. When the human body is exposed to the same allergen again, these allergens will combine with IgE antibodies, causing degranulation of mast cells and basophils, releasing allergic mediators such as histamine, leukotrienes, serotonin, and kinin. The action of these mediators on the correspon...

Claims

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Application Information

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IPC IPC(8): A61K31/78A61P11/02
Inventor 郭进军
Owner 郭进军
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