Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for preparing Tiopronin enteric-coated tablet

A technology for tiopronin intestinal and tiopronin tablets, which is applied in the field of raw materials, can solve the problems of inconspicuousness, patient resistance, and unfavorable medication for patients, and achieves the advantages of reducing specific odor, slight granule taste, and simple process. Effect

Active Publication Date: 2011-04-13
ベイジンカインバイオテックシーオーエルティーディー +1
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to its strong specific odor, most of the currently available products on the market cannot effectively cover up its odor, causing patients to have resistance to taking the drug, which is not conducive to the patient's medication
The method of increasing the thickness of the enteric-coated coating has a certain effect on masking the specific odor, but it is not obvious. At the same time, the dissolution of the enteric-coated tablet is slow, and the quality of the drug cannot be guaranteed.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The preparation of embodiment 1 tiopronin enteric-coated tablets

[0020] 1. Weigh 100 grams of tiopronin, 100 grams of starch, and 40 grams of microcrystalline cellulose, mix and pulverize, bond with 10% starch slurry, granulate with a 20-mesh sieve, dry with air at 50°C for 4 hours, and granulate with a 18-mesh sieve , add 2 grams of magnesium stearate, mix well, and compress into tablets to prepare tiopronin tablets;

[0021] 2. The water-soluble film-coating coating powder is formulated into a coating powder solution, and the plain tablet is coated with a film coating as an isolation layer, and the weight gain of the coating is 2.1%;

[0022] 3. The enteric coating coating powder is prepared into an enteric coating powder solution, and the product of the previous step is coated with an enteric coating, and the weight gain of the coating is 10.3%. Tiopronin enteric-coated tablets were prepared. Aluminum-plastic blister packaging, that is, the finished product.

Embodiment 2

[0023] The preparation of embodiment 2 tiopronin enteric-coated tablets

[0024] 1. Weigh 100 grams of tiopronin, 80 grams of starch, and 60 grams of microcrystalline cellulose, mix and pulverize, bond with 10% starch slurry, granulate with a 20-mesh sieve, dry with air at 50°C for 4 hours, and granulate with a 18-mesh sieve , add 1 gram of magnesium stearate, mix evenly, and compress into tablets to prepare tiopronin tablets;

[0025] 2. The water-soluble film-coating powder is formulated into a coating powder solution, and the plain tablet is coated with a film as an isolation layer. Coating weight gain 1.8%;

[0026] 3. The enteric-coating powder is prepared into an enteric-coating powder solution, and the product of the previous step is coated with an enteric-coating, and the weight gain of the coating is 12.1%. Tiopronin enteric-coated tablets were prepared. Aluminum-plastic blister packaging, that is, the finished product.

Embodiment 3

[0027] Example 3 Detection

[0028] Get the sample that embodiment 1 and embodiment 2 make detect, all no longer have the specific odor of raw material. According to the dissolution test, the above-mentioned samples had no change in tablet appearance in 0.1M hydrochloric acid solution for 2 hours, and the dissolution rates in pH 6.8 phosphate solution were 98.3% and 99.2% respectively after 45 minutes. Therefore, the tiopronin enteric-coated tablets prepared by the method of the present invention can effectively cover the specific odor of raw materials, and the dissolution meets the relevant national requirements.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a method for preparing Tiopronin enteric-coated tablet. The method comprises the steps of preparing Tiopronin tablet, tablet wrapping isolation clothes, wrapping enteric coating and the like. The Tiopronin enteric-coated tablet produced according to the method of the invention features simple technique and low cost, and can effectively cover the odor of Tiopronin.

Description

technical field [0001] The invention relates to the field of crude drugs, in particular to a preparation method of tiopronin enteric-coated tablets. Background technique [0002] Tiopronin is a glycine derivative created by Japan in 1963. It has low toxic and side effects and can be used for the treatment of chronic hepatitis and liver cirrhosis. It has been approved for use in Japan, Italy and other countries. [0003] Tiopronin is hydrolyzed by amidase in the body to generate glycine, which is mainly involved in the synthesis of purine nucleic acids, so it has the effect of promoting liver cell regeneration. It can activate superoxide dismutase and increase the detoxification function of the liver. Tiopronin can also promote the excretion of heavy metals and their poisons, and has important detoxification and liver protection effects. At present, it has been widely used clinically in the early treatment of viral hepatitis, alcoholic hepatitis, drug-induced hepatitis, hea...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/36A61K31/195A61P1/16A61P31/12
Inventor 张春丽周德胜吉春
Owner ベイジンカインバイオテックシーオーエルティーディー
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com